Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3. It induces early-stage apoptosis, arrests cell population at the G2/M phase, and moderately inhibits beclin-1 production in K562 leukemia cells, demonstrating greater inhibitory efficacy than SP600125. [1]
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Description | JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3. It induces early-stage apoptosis, arrests cell population at the G2/M phase, and moderately inhibits beclin-1 production in K562 leukemia cells, demonstrating greater inhibitory efficacy than SP600125. [1] |
Targets&IC50 | CYP2D6:26.7 nM, CYP3A4:383 nM, JNK3:10.5 nM, JNK2:10.5 nM, JNK1:1.82 nM |
In vitro | JNK-IN-14 (compound 11e) at concentrations of 2.5-5 μM for 24 hours induces slight early apoptosis in K562 cells in a concentration-dependent manner [1]. Compared to SP600125, JNK-IN-14 at concentrations ranging from 1.25-5 μM for 24 hours demonstrates enhanced inhibitory effects on K562 cell proliferation at higher concentrations [1]. |
Molecular Weight | 521.63 |
Formula | C27H31N5O4S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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JNK-IN-14 MAPK JNK inhibitor inhibit