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PROTACE3 Ligase Ligand-Linker Conjugate
E3 Ligase Ligand-Linker Conjugate consists of the ligand and linker from the E3 ubiquitin ligase, enabling the synthesis of PROTAC with target protein ligands. The E3 Ligase Ligand portion is often based on von Hippel-Lindau (VHL), MDM2, Cereblon (CRBN) , etc., while the linker portion commonly employs PEG chains, alkyl chains, or rigid aromatic rings. E3 Ligase Ligand-Linker Conjugate serves as a crucial tool for developing highly efficient and selective protein degradation agents.
TGN-020
Cited
TGN020
T510251987-99-6
TGN-020 is an inhibitor of Aquaporin 4 (AQP4, IC50: 3.1 μM), the most abundant water channel in the brain.
- $47
Size
QTY
CitedIberdomide Cited
CC-220
T77911323403-33-3
Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).
- $39
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QTY
Cited(S,R,S)-AHPC-Me
VHL ligand 2, E3 ligase Ligand 1A
T77521948273-02-6
(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is an (S,R,S)-AHPC-based VHL ligand used to recruit the von Hippel-Lindau (VHL) protein. It is utilized in the synthesis of ARV-771, a VHL E3 ligase-based BET PROTAC degrader that effectively degrades BET proteins in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
- $31
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QTY
Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride
T398762341841-02-7
Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl is an E3 ligase ligand-linker conjugate containing the E3 ubiquitin ligase cereblon (CRBN) and linker for the synthesis of PROTAC.
- $30
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QTY
Pomalidomide-PEG6-NH2 hydrochloride
T398752341841-01-6
Pomalidomide-PEG6-NH2 hydrochloride is an E3 ligase ligand-linker coupler consisting of a PEG linker and the E3 ligase cereblon ligand, Pomalidomide, commonly used in the synthesis of PROTAC molecules.Pomalidomide is an anti angiogenic agent and immunomodulator.
- $68
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QTY
Pomalidomide-C4-OH
T40014
Pomalidomide-C4-OH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology.
- $68
Size
QTY
Thalidomide-CH2CONH-C3-COOH
T40011
Thalidomide-CH2CONH-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and linker used in PROTAC technology.
- $68
Size
QTY
Thalidomide-CH2CONH-C2-COOH
T40012
Thalidomide-CH2CONH-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and linker used in PROTAC technology.
- $68
Size
QTY
Pomalidomide-CH2CONH-C2-COOH
T40006
Pomalidomide-CH2CONH-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology.
- $68
Size
QTY
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
T188192376990-30-4
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride, incorporating an E3 ligase ligand and a linker, can be used as an immunomodulator for the treatment of cancer.
- $42
Size
QTY
GMB-475
T84882490599-18-1
GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitination and subsequent degradation of th
- $45
Size
QTY
Pomalidomide-peg1-co2H
Pomalidomide-PEG1-C2-COOH
T400242139348-60-8In house
Pomalidomide-peg1-co2H is a synthetic E3 ligase ligand-linker conjugate containing a Pomalidomide-based cereblon ligand and a 2-unit PEG linker.
- $34
Size
QTY
Pomalidomide-PEG2-NH2 hydrochloride
T40015
Pomalidomide-PEG2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology.
- $68
Size
QTY
Pomalidomide-PEG2-COOH
Pomalidomide-PEG2-C2-acid, Pomalidomide 4'-PEG2-acid
T400252140807-17-4
Pomalidomide-PEG2-COOH is a synthetic E3 ligase ligand-linker conjugate containing a Pomalidomide-based cereblon ligand and a 2-unit PEG linker.
- $60
Size
QTY
BC-1215
T58211507370-20-8
BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release).
- $47
Size
QTY
Pomalidomide-PEG3-CO2H
Thalidomide-NH-PEG3-propionic acid
T400232138440-82-9
Pomalidomide-PEG3-CO2H (Thalidomide-NH-PEG3-propionic acid) is a synthesized E3 ligase ligand-linker conjugate. Pomalidomide-PEG3-CO2H incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
- $36
Size
QTY
(S,R,S)-AHPC-Me-C10-Br
T186682836297-55-1
(S,R,S)-AHPC-Me-C10-Br is a chemically synthesized conjugate and ligand-linker for E3 ligase, consisting of MS432 for MEK1/2 inhibitors and a VHL E3 ligase linker.
- $30
Size
QTY
Pomalidomide-C3-NH2 hydrochloride
T400022154342-45-5
Pomalidomide-C3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that integrates the Pomalidomide-based CRBN ligand and linker used in PROTAC technology.
- $35
Size
QTY
Pomalidomide-C2-COOH
T40005
Pomalidomide-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology.
- $68
Size
QTY
(S,R,S)-AHPC-C4-NH2 hydrochloride
VHL Ligand-Linker Conjugates 13, VH032-C4-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 28
T186402245697-83-8
(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) is a synthesized E3 ligase ligand-linker conjugate comprising the (S,R,S)-AHPC-based VHL ligand and a linker.
- $32
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QTY
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride
T188182204226-02-6
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker. This compound is used in the synthesis of PROTACs.
- $31
Size
QTY
(S,R,S)-AHPC
VHL ligand 1, VH032-NH2, MDK7526
T84121448297-52-6
(S,R,S)-AHPC (VH032-NH2) is a VH032-based ligand for recruiting the von Hippel-Lindau (VHL) protein, potentially useful for the targeted degradation of the androgen receptor.
- $36
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QTY
Pomalidomide-C7-NH2 hydrochloride
T400042093387-55-2
Pomalidomide-C7-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology.
- $45
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QTY
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