Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LYP-IN-4 (compound D14), a reversible and selective lymphotyrosine phosphatase (LYP) inhibitor (Ki=1.34 μM, IC50=3.52μM), regulates TCR signaling, increases PD-1/PD-L1 expression, and strengthens anti-tumor immunity. It also stimulates T cell activation, impedes M2 macrophage polarization, and suppresses tumor progression in MC38 isogenic mouse models.
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Description | LYP-IN-4 (compound D14), a reversible and selective lymphotyrosine phosphatase (LYP) inhibitor (Ki=1.34 μM, IC50=3.52μM), regulates TCR signaling, increases PD-1/PD-L1 expression, and strengthens anti-tumor immunity. It also stimulates T cell activation, impedes M2 macrophage polarization, and suppresses tumor progression in MC38 isogenic mouse models. |
In vitro | LYP-IN-4 (compound D14) also inhibits other protein tyrosine phosphatases (PTP), with respective IC50 values of 13.7 μM (PTP1B) and 12.3 μM (PTPN1B) [1]. |
In vivo | LYP-IN-4 (compound D14) administered at 25 mg/kg through oral gavage twice daily for a continuous duration of 14 days significantly inhibited tumor growth and reduced tumor volume in the MC38 genetic model without a decrease in mouse body weight [1]. |
Molecular Weight | 593 |
Formula | C29H21ClN2O8S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
LYP-IN-4 Metabolism Phosphatase inhibitor inhibit