Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BPDA2 is a highly selective and competitive SHP2 inhibitor, exhibiting IC50 values of 92.0 nM for SHP2, and 33.39 μM and 40.71 μM for SHP1 and SHP1B, respectively. This compound effectively downregulates mitogenic and cell survival signaling, including reducing expression of receptor tyrosine kinases (RTKs). Furthermore, BPDA2 suppresses SHP2-mediated signaling, leading to the inhibition of breast cancer cell phenotypes [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 1,520.00 | |
50 mg | In stock | $ 1,980.00 | |
100 mg | In stock | $ 2,500.00 |
Description | BPDA2 is a highly selective and competitive SHP2 inhibitor, exhibiting IC50 values of 92.0 nM for SHP2, and 33.39 μM and 40.71 μM for SHP1 and SHP1B, respectively. This compound effectively downregulates mitogenic and cell survival signaling, including reducing expression of receptor tyrosine kinases (RTKs). Furthermore, BPDA2 suppresses SHP2-mediated signaling, leading to the inhibition of breast cancer cell phenotypes [1]. |
In vitro | BPDA2, at concentrations ranging from 0.2 to 3.2 μM, concentration-dependently inhibits the basal activation of Akt and ERK1/2 [1]. In addition, BPDA2 (0.25-4.0 μM; for 10 days) suppresses anchorage-independent growth and cancer stem cell characteristics in breast cancer cells in a concentration-dependent manner [1]. |
Molecular Weight | 398.49 |
Formula | C24H30O5 |
CAS No. | 2907659-86-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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BPDA2 2907659-86-1 inhibitor inhibit