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Ontuxizumab (Synonyms: MORAb-004)

Catalog No. T77374 Copy Product Info
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Ontuxizumab (MORAb-004) is a potent IgG1/κ monoclonal antibody targeting endomelanic acid with anti-tumor effects. It specifically targets endothelin (TEM-1 or CD248) and is used for the treatment of metastatic melanoma.

Ontuxizumab

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Catalog No. T77374
Synonyms MORAb-004

Ontuxizumab (MORAb-004) is a potent IgG1/κ monoclonal antibody targeting endomelanic acid with anti-tumor effects. It specifically targets endothelin (TEM-1 or CD248) and is used for the treatment of metastatic melanoma.

Ontuxizumab
Cas No. 946415-62-9
Pack SizePriceUSA StockGlobal StockQuantity
1 mg$297-In Stock
5 mg$788-In Stock
10 mg$1,230-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:97.91% (SDS-PAGE); 99.85% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction

Bioactivity
Description
Ontuxizumab (MORAb-004) is a potent IgG1/κ monoclonal antibody targeting endomelanic acid with anti-tumor effects. It specifically targets endothelin (TEM-1 or CD248) and is used for the treatment of metastatic melanoma.
In vitro
Ontuxizumab induces internalization of CD248 in a dose-dependent manner, with a reduction of 46% in surface CD248 on human dermal fibroblasts after 12 hours of treatment with concentrations ranging from 0 to 100 μg/mL[1].
In vivo
In human CD248 knock-in mice, Ontuxizumab demonstrates antitumor effects when administered at a dose of 50 mg/kg via intravenous injection, given five times a day for five consecutive days[1].
SynonymsMORAb-004
Reactivity
Human
Application
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Gene ID
Uniprot ID
TargetTEM1/Endosialin/CD248
Chemical Properties
Molecular Weight145 kDa
Cas No.946415-62-9
Antibody Information
IsotypeHuman IgG1 kappa
Recommended Isotype Control
Storage & Solubility Information
Storagestore at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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