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Moscatin
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Catalog No. TN1954Cas No. 108335-06-4
Alias Plicatol, 4-methoxyphenanthrene-2,5-diol
Moscatin (Plicatol, 4-methoxyphenanthrene-2,5-diol) is a diphenyl derivative that can be extracted from Dendrobium nobile Lindl. It inhibits arachidonic acid-induced platelet aggregation, and is able to inhibit Candida albicans virulence and growth by down-regulating the expression of genes such as ERG, HSP, and ALS.
Moscatin
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Purity: 99.89%
Catalog No. TN1954Alias Plicatol, 4-methoxyphenanthrene-2,5-diolCas No. 108335-06-4
Moscatin (Plicatol, 4-methoxyphenanthrene-2,5-diol) is a diphenyl derivative that can be extracted from Dendrobium nobile Lindl. It inhibits arachidonic acid-induced platelet aggregation, and is able to inhibit Candida albicans virulence and growth by down-regulating the expression of genes such as ERG, HSP, and ALS.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $183 | - | In Stock | |
| 5 mg | $456 | - | In Stock | |
| 10 mg | $670 | - | In Stock | |
| 25 mg | $1,050 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.89%
Appearance:Solid
Color:Brown
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Moscatin (Plicatol, 4-methoxyphenanthrene-2,5-diol) is a diphenyl derivative that can be extracted from Dendrobium nobile Lindl. It inhibits arachidonic acid-induced platelet aggregation, and is able to inhibit Candida albicans virulence and growth by down-regulating the expression of genes such as ERG, HSP, and ALS. |
| Targets&IC50 | AA-induced platelet aggregation:37.2 μM |
| In vitro | Moscatin inhibits washed rabbit platelet aggregation in a concentration-dependent manner, showing complete inhibition of AA- and collagen-induced aggregation at 100 μg/mL. Moscatin IC₅₀ against AA-induced aggregation is 37.2 μM, likely by interfering with thromboxane A₂ formation [1]. |
| In vivo | In mouse infection models (systemic and OPC), moscatin injection (20 μg/mL, 200 μL) significantly reduced the pathogenicity of Candida albicans SC5314 [2]. Moscatin restored gut microbiota balance in Candida albicans-infected mice, increasing beneficial bacteria levels and reducing fungal burden [2]. |
| Synonyms | Plicatol, 4-methoxyphenanthrene-2,5-diol |
| Molecular Weight | 240.25 |
| Formula | C15H12O3 |
| Cas No. | 108335-06-4 |
| Smiles | OC=1C=C(OC)C2=C(C=CC=3C=CC=C(O)C32)C1 |
| Relative Density. | 1.345g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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