PROTAC TTK degrader-2

Name: PROTAC TTK degrader-2
Brand: TargetMol
SKU: T81374
Rating: 4.5 (1 reviews)

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Catalog No. T81374Cas No. 2953426-48-5

PROTAC TTK Degrader-2 is a potent threonine tyrosine kinase (TTK) PROTAC degrader, achieving DC50 values of 3.1 nM in COLO-205 cells and 12.4 nM in HCT-116 cells. It demonstrates effective target degradation and anticancer activity in a COLO-205 human colorectal cancer cell xenograft mouse model [1].

PROTAC TTK degrader-2

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Catalog No. T81374Cas No. 2953426-48-5

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Product Introduction

Bioactivity

Description	PROTAC TTK Degrader-2 is a potent threonine tyrosine kinase (TTK) PROTAC degrader, achieving DC50 values of 3.1 nM in COLO-205 cells and 12.4 nM in HCT-116 cells. It demonstrates effective target degradation and anticancer activity in a COLO-205 human colorectal cancer cell xenograft mouse model [1].
In vitro	PROTAC TTK degrader-2 (compound 8j), at concentrations from 0 to 10 μM over 96 hours, inhibits cancer cell proliferation [1].
In vivo	PROTAC TTK degrader-2 (8j) administered intraperitoneally at 10 mg/kg exhibits satisfactory pharmacokinetic profiles [1]. Daily intraperitoneal dosing of 10 or 20 mg/kg for 16 days significantly reduces TTK protein levels and suppresses tumor growth [1]. Pharmacokinetic parameters for PROTAC TTK degrader-2 were established in male SD rats [1].

Chemical Properties

Molecular Weight	884.03
Formula	C₄₉H₅₇N₉O₇
Cas No.	2953426-48-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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