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TNG260
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Catalog No. T73520Cas No. 2935964-98-8
Alias TNG-260, TNG 260
TNG260 is a selective and orally effective inhibitor of HDAC1 and the CoREST complex, exhibiting 10-fold selectivity for HDAC1 over HDAC3 and 500-fold selectivity for CoREST over NuRD and Sin3 complexes. TNG260 reshapes the tumor immune microenvironment by reducing immunosuppressive neutrophil infiltration, enhancing effector T-cell recruitment, reversing anti-PD-1 resistance driven by STK11 deficiency, and inducing durable tumor regression in combination with α-PD-1 in STK11-mutant MC38 tumor models while maintaining lower bone marrow toxicity than non-selective HDAC inhibitors.
TNG260
😃Good
Purity: 99.78%
Catalog No. T73520Alias TNG-260, TNG 260Cas No. 2935964-98-8
TNG260 is a selective and orally effective inhibitor of HDAC1 and the CoREST complex, exhibiting 10-fold selectivity for HDAC1 over HDAC3 and 500-fold selectivity for CoREST over NuRD and Sin3 complexes. TNG260 reshapes the tumor immune microenvironment by reducing immunosuppressive neutrophil infiltration, enhancing effector T-cell recruitment, reversing anti-PD-1 resistance driven by STK11 deficiency, and inducing durable tumor regression in combination with α-PD-1 in STK11-mutant MC38 tumor models while maintaining lower bone marrow toxicity than non-selective HDAC inhibitors.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $293 | - | In Stock | |
| 5 mg | $722 | - | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,520 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock | |
| 100 mg | $2,500 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.78%
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | TNG260 is a selective and orally effective inhibitor of HDAC1 and the CoREST complex, exhibiting 10-fold selectivity for HDAC1 over HDAC3 and 500-fold selectivity for CoREST over NuRD and Sin3 complexes. TNG260 reshapes the tumor immune microenvironment by reducing immunosuppressive neutrophil infiltration, enhancing effector T-cell recruitment, reversing anti-PD-1 resistance driven by STK11 deficiency, and inducing durable tumor regression in combination with α-PD-1 in STK11-mutant MC38 tumor models while maintaining lower bone marrow toxicity than non-selective HDAC inhibitors. |
| In vivo | In syngeneic and Genetically Engineered Mouse Models (GEMM) of STK11-mutant NSCLC, TNG260 was evaluated in combination with anti-PD1 therapy. This combination inhibited tumor growth in KRAS/STK11 mutant NSCLC tumors. The treatment modulated the tumor microenvironment, characterized by increased markers of macrophages, neutrophils, and dendritic cells within the tumor. No toxicity was observed in the mice [2]. |
| Synonyms | TNG-260, TNG 260 |
| Molecular Weight | 383.44 |
| Formula | C20H18FN3O2S |
| Cas No. | 2935964-98-8 |
| Smiles | O=C(C1=CC=C(C=C1)S(C)(=N)=O)NC2=C(N)C=CC(C3=CC=C(C=C3)F)=C2 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 1.7 mg/mL (4.43 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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