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Manelimab (Synonyms: BCD-135)
Catalog No. T77079 Copy Product Info
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Manelimab is a humanized monoclonal antibody targeting Programmed death-ligand 1(PD-L1). By blocking the interaction between PD-L1 and its receptor PD-1, it can relieve the immunosuppression of T cells, thus enhancing the anti-tumor immune response. Manelimab is mainly used to explore the mechanism of tumor immunotherapy.
Manelimab
Copy Product Info🥰Excellent
Catalog No. T77079
Synonyms BCD-135
Manelimab is a humanized monoclonal antibody targeting Programmed death-ligand 1(PD-L1). By blocking the interaction between PD-L1 and its receptor PD-1, it can relieve the immunosuppression of T cells, thus enhancing the anti-tumor immune response. Manelimab is mainly used to explore the mechanism of tumor immunotherapy.
Manelimab
Cas No. 2168561-26-8
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
Antibody Information
Storage & Solubility Information
| Description | Manelimab is a humanized monoclonal antibody targeting Programmed death-ligand 1(PD-L1). By blocking the interaction between PD-L1 and its receptor PD-1, it can relieve the immunosuppression of T cells, thus enhancing the anti-tumor immune response. Manelimab is mainly used to explore the mechanism of tumor immunotherapy. |
| In vitro | Manelimab binds human IL-10Ra with high affinity, triggering STAT3 phosphorylation and mimicking IL-10 signaling. It dose-dependently inhibits the secretion of pro-inflammatory cytokines (e.g., TNF-alpha, IL-6) in LPS-stimulated monocytes at nanomolar (nM) concentrations [1]. |
| Synonyms | BCD-135 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | PD-L1 |
| Cas No. | 2168561-26-8 |
| Isotype | IgG1 |
| Storage | Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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