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Aditoprime

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Catalog No. T60699Cas No. 56066-63-8
Alias Aditoprime, Aditoprim

Aditoprime (Aditoprim) is a selective inhibitor of bacterial dihydrofolate reductase (DHFR) that exhibits potent enzymatic inhibition with IC50 values of 47 nM for Escherichia coli DHFR and 520 nM for Lactobacillus casei DHFR, Aditoprime functions by blocking the conversion of dihydrofolic acid to tetrahydrofolic acid.Aditoprime also demonstrate broad-spectrum antibacterial activity combined with favorable pharmacokinetic properties that support its use in antimicrobial research and drug development studies.

Aditoprime

Aditoprime

😃Good
Purity: 99.89%
Catalog No. T60699Alias Aditoprime, AditoprimCas No. 56066-63-8
Aditoprime (Aditoprim) is a selective inhibitor of bacterial dihydrofolate reductase (DHFR) that exhibits potent enzymatic inhibition with IC50 values of 47 nM for Escherichia coli DHFR and 520 nM for Lactobacillus casei DHFR, Aditoprime functions by blocking the conversion of dihydrofolic acid to tetrahydrofolic acid.Aditoprime also demonstrate broad-spectrum antibacterial activity combined with favorable pharmacokinetic properties that support its use in antimicrobial research and drug development studies.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$107-In Stock
5 mg$263-In Stock
10 mg$428-In Stock
25 mg$818-In Stock
50 mg$1,280-In Stock
100 mg$1,760-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.89%
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Product Introduction

Bioactivity
Description
Aditoprime (Aditoprim) is a selective inhibitor of bacterial dihydrofolate reductase (DHFR) that exhibits potent enzymatic inhibition with IC50 values of 47 nM for Escherichia coli DHFR and 520 nM for Lactobacillus casei DHFR, Aditoprime functions by blocking the conversion of dihydrofolic acid to tetrahydrofolic acid.Aditoprime also demonstrate broad-spectrum antibacterial activity combined with favorable pharmacokinetic properties that support its use in antimicrobial research and drug development studies.
Targets&IC50
DHFR (E.coli):47 nM, DHFR (L.casei):520 nM
In vitro
Method: Antibacterial susceptibility testing was performed against bacterial isolates from swine, poultry, calves, sheep, and fish.
Result: Aditoprime demonstrated broad antibacterial activity comparable to trimethoprim, with MIC or MIC₅₀ values ≤ 4 μg/mL against multiple Gram-negative and Gram-positive pathogens[1].
In vivo
Method: Aditoprime was administered intramuscularly at doses of 10–40 mg/kg body weight in swine infected with Streptococcus, and pharmacokinetic parameters were evaluated across pigs, calves, monkeys, and sheep.
Result: Aditoprime showed longer elimination half-lives (3.3–14.8 h), larger distribution volumes (4.6–10.4 L/kg), and effectively treated swine streptococcosis at 10–40 mg/kg.[1]
SynonymsAditoprime, Aditoprim
Chemical Properties
Molecular Weight303.36
FormulaC15H21N5O2
Cas No.56066-63-8
SmilesN=1C=C(C(=NC1N)N)CC2=CC(OC)=C(C(OC)=C2)N(C)C
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (263.71 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2964 mL16.4821 mL32.9641 mL164.8207 mL
5 mM0.6593 mL3.2964 mL6.5928 mL32.9641 mL
10 mM0.3296 mL1.6482 mL3.2964 mL16.4821 mL
20 mM0.1648 mL0.8241 mL1.6482 mL8.2410 mL
50 mM0.0659 mL0.3296 mL0.6593 mL3.2964 mL
100 mM0.0330 mL0.1648 mL0.3296 mL1.6482 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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