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BODIPY-aminoacetaldehyde diethyl acetal

Catalog No. T35568 CAS 247069-93-8

BODIPY-aminoacetaldehyde diethyl acetal (BAAA-DA) is a stable precursor to BODIPY-aminoacetaldehyde, a cell-permeable fluorescent substrate for aldehyde dehydrogenase (ALDH).1,2BODIPY-aminoacetaldehyde diethyl acetal is converted under acidic conditions to BODIPY-aminoacetaldehyde (BAAA).2BAAA is cell-permeant and is converted intracellularly by ALDH to BODIPY aminoacetate (BAA), which is retained by cells and can be used to identify cells with high ALDH activity.1BAA is a substrate for the efflux pump P-glycoprotein (P-gp) but co-application of BAAA with a P-gp inhibitor, such as verapamil , inhibits BAA efflux.2BAAA-DA has been used to isolate human hematopoietic progenitor cells, which have high ALDH activity, andviaflow cytometry to sort cancer stem cells that contain high levels of ALDH.1,3BAA used in cells can be excited at 488 nm and displays an emission maximum of 512 nm.4

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BODIPY-aminoacetaldehyde diethyl acetal Chemical Structure

BODIPY-aminoacetaldehyde diethyl acetal, CAS 247069-93-8

Pack Size	Availability	Price/USD
50 μg	35 days	$ 183.00
100 μg	35 days	$ 345.00
500 μg	35 days	$ 1,430.00
1 mg	35 days	$ 2,500.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	407.27
Formula	C20H28BF2N3O3
CAS No.	247069-93-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Storms, R.W., Trujillo, A.P., Springer, J.B., et al.Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activityProceedings of the National Academy of Sciences of the United States of America96(16)9118-9123(1999) 2. Smith, C.A., Colvin, M., Storms, R.W., et al.BODIPY aminoacetaldehyde diethyl acetal08010501.81-15(2010) 3. Leng, Z., Yang, Z., Li, L., et al.A reliable method for the sorting and identification of ALDHhigh cancer stem cells by flow cytometryExp. Ther. Med.(2017) 4. Pomper, M.G., Wang, H., Minn, I., et al.Red fluorescent aldehyde dehydrogenase (ALDH) substrate(2015)

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Keywords

BODIPY-aminoacetaldehyde diethyl acetal 247069-93-8 BODIPY aminoacetaldehyde diethyl acetal BODIPYaminoacetaldehyde diethyl acetal inhibitor inhibit

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