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Bivamelagon

Name: Bivamelagon
Brand: TargetMol
SKU: T79090
Price: 527 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T79090Cas No. 2641595-54-0

Alias MC-4R Agonist 2

Bivamelagon (LB54640) is an orally effective MC4R (melanocortin 4) agonist with the advantage of crossing the blood-brain barrier, suitable for studying hypothalamic obesity and diabetes.

Bivamelagon

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Purity: 100%

Catalog No. T79090Alias MC-4R Agonist 2Cas No. 2641595-54-0

Bivamelagon (LB54640) is an orally effective MC4R (melanocortin 4) agonist with the advantage of crossing the blood-brain barrier, suitable for studying hypothalamic obesity and diabetes.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$527	-	In Stock
5 mg	$1,130	-	In Stock
10 mg	$1,530	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:100%

ee:100%

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Product Introduction

Bioactivity

Description	Bivamelagon (LB54640) is an orally effective MC4R (melanocortin 4) agonist with the advantage of crossing the blood-brain barrier, suitable for studying hypothalamic obesity and diabetes.
Targets&IC50	MC4R:65 nM (Ki)
In vitro	Bivamelagon exhibits β-arrestin recruitment activity in U2OS cells expressing MC4R and β-arrestin, with an EC₅₀ value of 4.6 nM for this activity at a duration of 90 minutes [1].
In vivo	Bivamelagon (10-30 mg/kg, oral administration, 16 days) exhibited weight loss effects in a mouse model of obesity [1].
Synonyms	MC-4R Agonist 2

Chemical Properties

Molecular Weight	629.27
Formula	C₃₅H₅₃ClN₄O₄
Cas No.	2641595-54-0
Smiles	C(=O)(N1[C@H](C(=O)N2CCOCC2)C[C@H](N(C(C(C)C)=O)[C@@H]3CC[C@H](C)CC3)C1)[C@H]4[C@@H](CN(C(C)(C)C)C4)C5=CC=C(Cl)C=C5
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (158.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5891 mL	7.9457 mL	15.8914 mL	79.4571 mL
5 mM	0.3178 mL	1.5891 mL	3.1783 mL	15.8914 mL
10 mM	0.1589 mL	0.7946 mL	1.5891 mL	7.9457 mL
20 mM	0.0795 mL	0.3973 mL	0.7946 mL	3.9729 mL
50 mM	0.0318 mL	0.1589 mL	0.3178 mL	1.5891 mL
100 mM	0.0159 mL	0.0795 mL	0.1589 mL	0.7946 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc