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Bivamelagon

Name: Bivamelagon
Brand: TargetMol
SKU: T79090
Price: 279 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T79090Cas No. 2641595-54-0

Alias MC-4R Agonist 2

Bivamelagon (LB54640) is an orally effective MC4R (melanocortin 4) agonist with the advantage of crossing the blood-brain barrier, suitable for studying hypothalamic obesity and diabetes.

Bivamelagon

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Purity: 100%

Catalog No. T79090Alias MC-4R Agonist 2Cas No. 2641595-54-0

Bivamelagon (LB54640) is an orally effective MC4R (melanocortin 4) agonist with the advantage of crossing the blood-brain barrier, suitable for studying hypothalamic obesity and diabetes.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$279	-	In Stock
5 mg	$679	-	In Stock
1 mL x 10 mM (in DMSO)	$938	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:100%

ee:100%

Appearance:Solid

Color:White

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COA HNMR LCMS ORP CSFC

Product Introduction

Bioactivity

Description	Bivamelagon (LB54640) is an orally effective MC4R (melanocortin 4) agonist with the advantage of crossing the blood-brain barrier, suitable for studying hypothalamic obesity and diabetes.
Targets&IC50	MC4R:65 nM (Ki)
In vitro	Bivamelagon exhibits β-arrestin recruitment activity in U2OS cells expressing MC4R and β-arrestin, with an EC₅₀ value of 4.6 nM for this activity at a duration of 90 minutes [1].
In vivo	Bivamelagon (10-30 mg/kg, oral administration, 16 days) exhibited weight loss effects in a mouse model of obesity [1].
Synonyms	MC-4R Agonist 2

Chemical Properties

Molecular Weight	629.27
Formula	C₃₅H₅₃ClN₄O₄
Cas No.	2641595-54-0
Smiles	C(=O)(N1[C@H](C(=O)N2CCOCC2)C[C@H](N(C(C(C)C)=O)[C@@H]3CC[C@H](C)CC3)C1)[C@H]4[C@@H](CN(C(C)(C)C)C4)C5=CC=C(Cl)C=C5

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (158.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5891 mL	7.9457 mL	15.8914 mL	79.4571 mL
5 mM	0.3178 mL	1.5891 mL	3.1783 mL	15.8914 mL
10 mM	0.1589 mL	0.7946 mL	1.5891 mL	7.9457 mL
20 mM	0.0795 mL	0.3973 mL	0.7946 mL	3.9729 mL
50 mM	0.0318 mL	0.1589 mL	0.3178 mL	1.5891 mL
100 mM	0.0159 mL	0.0795 mL	0.1589 mL	0.7946 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc