Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tubulin/HDAC-IN-3 (compound 12a) serves as a potent dual inhibitor of tubulin polymerization and HDAC1/8, exhibiting IC50 values of 5.4 μM for tubulin polymerization, and 0.155 and 0.177 μM for HDAC1 and HDAC8, respectively. Its mechanism of action includes obstructing the cell cycle, triggering apoptosis, and suppressing colony formation [1].
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Description | Tubulin/HDAC-IN-3 (compound 12a) serves as a potent dual inhibitor of tubulin polymerization and HDAC1/8, exhibiting IC50 values of 5.4 μM for tubulin polymerization, and 0.155 and 0.177 μM for HDAC1 and HDAC8, respectively. Its mechanism of action includes obstructing the cell cycle, triggering apoptosis, and suppressing colony formation [1]. |
Targets&IC50 | HDAC8:0.177 μM, HDAC6:1.037 μM, HDAC1:0.155 μM |
In vitro | Tubulin/HDAC-IN-3 (compound 12a) demonstrated antiproliferative activity in vitro against four cancer cell lines—BE-(2)-C, A549, U87MG, and HCT116—with IC50 values of 0.017 ± 0.002, 0.053 ± 0.003, 0.056 ± 0.005, and 0.051 ± 0.003 μM, respectively [1]. |
In vivo | Tubulin/HDAC-IN-3 (compound 12a), administered at a dose of 25 mg/kg via intraperitoneal injection every three days, demonstrated significant antitumor efficacy in mice [1]. |
Molecular Weight | 552.53 |
Formula | C28H28N2O10 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Tubulin/HDAC-IN-3 inhibitor inhibit