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Nitracrine dihydrochloride hydrate

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Catalog No. T87011Cas No. 55429-45-3
Alias Nitracrine dihydrochloride monohydrate, Nitracrine 2HCl monohydrate

Nitracrine (dihydrochloride hydrate), a 1-nitroacridine derivative, inhibits RNA synthesis, reversibly binds to DNA, and forms covalent adducts with DNA in vivo. It is a potent hypoxia-selective and antitumor agent in vitro, exhibiting cytotoxicity towards most cells [1] [2] [3].

Nitracrine dihydrochloride hydrate
Other Forms of Nitracrine dihydrochloride hydrate:

Nitracrine dihydrochloride hydrate

😃Good
Catalog No. T87011Alias Nitracrine dihydrochloride monohydrate, Nitracrine 2HCl monohydrateCas No. 55429-45-3
Nitracrine (dihydrochloride hydrate), a 1-nitroacridine derivative, inhibits RNA synthesis, reversibly binds to DNA, and forms covalent adducts with DNA in vivo. It is a potent hypoxia-selective and antitumor agent in vitro, exhibiting cytotoxicity towards most cells [1] [2] [3].
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10 mgInquiry10-14 weeks10-14 weeks
50 mgInquiry10-14 weeks10-14 weeks
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Bioactivity
Description
Nitracrine (dihydrochloride hydrate), a 1-nitroacridine derivative, inhibits RNA synthesis, reversibly binds to DNA, and forms covalent adducts with DNA in vivo. It is a potent hypoxia-selective and antitumor agent in vitro, exhibiting cytotoxicity towards most cells [1] [2] [3].
In vitro
Nitracrine (2 μM; 1 h) causes 50% mortality in human erythroleukemia K562 cells when exposed to light for 48 minutes, while it requires 8.5 hours in darkness [3]. The LD50 values for nitracrine in P388, NIH3T3, and K562 cells are 0.23 μM, 0.6 μM, and 0.16 μM, respectively, after 1 hour of incubation under light [3]. Cell Viability Assay [3] Cell Line: Human erythroleukemia K562 cells Concentration: 2 μM Incubation Time: 1h Result: Achieved 50% cell death under 48 minutes of illumination.
SynonymsNitracrine dihydrochloride monohydrate, Nitracrine 2HCl monohydrate
Chemical Properties
Molecular Weight415.31
FormulaC18H24Cl2N4O3
Cas No.55429-45-3
SmilesCN(C)CCCNC1=C(C=CC=C2)C2=NC3=C1C([N+]([O-])=O)=CC=C3.Cl.O.Cl
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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