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SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi)
(Synonyms: Replicase polyprotein 1a, pp1a, PL-PRO, Plpro, PL2-PRO, Papain-like Protease, nsp1) Copy Product InfoSynonyms: Replicase polyprotein 1a, pp1a, PL-PRO, Plpro, PL2-PRO, Papain-like Protease, nsp1
Catalog No. TMPK-01352 Copy Product Info
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi) is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 38.6 kDa and the accession number is P0C6U8.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 µg | $48 | 7-10 days | 7-10 days | |
| 20 µg | $74 | 7-10 days | 7-10 days | |
| 50 µg | $138 | 7-10 days | 7-10 days | |
| 100 µg | $231 | 7-10 days | 7-10 days | |
| 200 µg | $419 | 7-10 days | 7-10 days | |
| 500 µg | $932 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi) is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 38.6 kDa and the accession number is P0C6U8. |
| Species | SARS |
| Expression System | E. coli |
| Tag | N-His-Avi |
| Accession Number | P0C6U8 |
| Construction | Glu1-Ile314 |
| Protein Purity | > 95% as determined by Tris-Bis PAGE |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Supplied as 0.22 μm filtered solution in 20 mM Tris, 100 mM NaCl, 10% Glycerol (pH 7.8). |
| Synonyms | Replicase polyprotein 1a, pp1a, PL-PRO, Plpro, PL2-PRO, Papain-like Protease, nsp1 |
| Research Background | The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. |
| Molecular Weight | 38.6 kDa (predicted) same as Tris-Bis PAGE result. |
| Shipping | Proteins are shipped with blue ice. |
| Storage | It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi) chemical structure | SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi) molecular weight
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