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(R)-Elexacaftor

Name: (R)-Elexacaftor
Brand: TargetMol
SKU: T78240
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78240Cas No. 2229860-99-3

Alias 2-O-Glucosyloxy-4-methoxycinnamic acid

(R)-Elexacaftor (compound 37) is the enantiomer of Elexacaftor (compound 1). (R)-Elexacaftor is a CFTR modulator with an EC50 of 0.29 μM for CFTR dF508.

(R)-Elexacaftor

🥰Excellent

Purity: 98.991%

Catalog No. T78240Alias 2-O-Glucosyloxy-4-methoxycinnamic acidCas No. 2229860-99-3

(R)-Elexacaftor (compound 37) is the enantiomer of Elexacaftor (compound 1). (R)-Elexacaftor is a CFTR modulator with an EC50 of 0.29 μM for CFTR dF508.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	-	In Stock
5 mg	$255	-	In Stock
10 mg	$413	-	In Stock
25 mg	$815	-	In Stock
50 mg	$1,230	-	In Stock
100 mg	$1,990	-	In Stock
200 mg	$2,680	-	In Stock
1 mL x 10 mM (in DMSO)	$337	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.991%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	(R)-Elexacaftor (compound 37) is the enantiomer of Elexacaftor (compound 1). (R)-Elexacaftor is a CFTR modulator with an EC50 of 0.29 μM for CFTR dF508.
Targets&IC50	F508del CFTR:0.29 uM (EC50)
Synonyms	2-O-Glucosyloxy-4-methoxycinnamic acid

Chemical Properties

Molecular Weight	597.65
Formula	C₂₆H₃₄F₃N₇O₄S
Cas No.	2229860-99-3
Smiles	C(NS(=O)(=O)C1=CN(C)N=C1C)(=O)C2=C(N=C(C=C2)N3N=C(OCC(C(F)(F)F)(C)C)C=C3)N4C[C@H](C)CC4(C)C
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (133.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6732 mL	8.3661 mL	16.7322 mL	83.6610 mL
5 mM	0.3346 mL	1.6732 mL	3.3464 mL	16.7322 mL
10 mM	0.1673 mL	0.8366 mL	1.6732 mL	8.3661 mL
20 mM	0.0837 mL	0.4183 mL	0.8366 mL	4.1831 mL
50 mM	0.0335 mL	0.1673 mL	0.3346 mL	1.6732 mL
100 mM	0.0167 mL	0.0837 mL	0.1673 mL	0.8366 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc