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(R)-Elexacaftor

🥰Excellent
Catalog No. T78240Cas No. 2229860-99-3
Alias 2-O-Glucosyloxy-4-methoxycinnamic acid

(R)-Elexacaftor (compound 37) is the enantiomer of Elexacaftor (compound 1). (R)-Elexacaftor is a CFTR modulator with an EC50 of 0.29 μM for CFTR dF508.

(R)-Elexacaftor

(R)-Elexacaftor

🥰Excellent
Purity: 98.991%
Catalog No. T78240Alias 2-O-Glucosyloxy-4-methoxycinnamic acidCas No. 2229860-99-3
(R)-Elexacaftor (compound 37) is the enantiomer of Elexacaftor (compound 1). (R)-Elexacaftor is a CFTR modulator with an EC50 of 0.29 μM for CFTR dF508.
Pack SizePriceAvailabilityQuantity
1 mg$98In Stock
5 mg$255In Stock
10 mg$413In Stock
25 mg$815In Stock
50 mg$1,230In Stock
100 mg$1,990In Stock
200 mg$2,680In Stock
1 mL x 10 mM (in DMSO)$337In Stock
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.991%
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Product Introduction

Bioactivity
Description
(R)-Elexacaftor (compound 37) is the enantiomer of Elexacaftor (compound 1). (R)-Elexacaftor is a CFTR modulator with an EC50 of 0.29 μM for CFTR dF508.
Targets&IC50
F508del CFTR:0.29 uM (EC50)
Synonyms2-O-Glucosyloxy-4-methoxycinnamic acid
Chemical Properties
Molecular Weight597.65
FormulaC26H34F3N7O4S
Cas No.2229860-99-3
SmilesC(NS(=O)(=O)C1=CN(C)N=C1C)(=O)C2=C(N=C(C=C2)N3N=C(OCC(C(F)(F)F)(C)C)C=C3)N4C[C@H](C)CC4(C)C
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (133.86 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6732 mL8.3661 mL16.7322 mL83.6610 mL
5 mM0.3346 mL1.6732 mL3.3464 mL16.7322 mL
10 mM0.1673 mL0.8366 mL1.6732 mL8.3661 mL
20 mM0.0837 mL0.4183 mL0.8366 mL4.1831 mL
50 mM0.0335 mL0.1673 mL0.3346 mL1.6732 mL
100 mM0.0167 mL0.0837 mL0.1673 mL0.8366 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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