Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-Methionine γ-lyase (Methionine lyase), a multifaceted enzyme in the γ-family of pyridoxal-5’-phosphate (PLP)-dependent enzymes, catalyzes the α, γ-elimination of L-methionine and homocysteine. This enzyme exhibits anticancer and anti-infectious properties and is utilized in homocysteinemia research [1] [2] [3].
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Description | L-Methionine γ-lyase (Methionine lyase), a multifaceted enzyme in the γ-family of pyridoxal-5’-phosphate (PLP)-dependent enzymes, catalyzes the α, γ-elimination of L-methionine and homocysteine. This enzyme exhibits anticancer and anti-infectious properties and is utilized in homocysteinemia research [1] [2] [3]. |
In vitro | L-Methionine γ-lyase (Methionine lyase) demonstrates anticancer activity against liver cancer cell lines (Hep-G2 and HCT-116) at concentrations up to 1000 μg/mL over 24 hours [1]. Furthermore, L-Methionine γ-lyase exhibits cytotoxicity toward a range of cancer cells, including colorectal, hepatocellular, ovarian adenocarcinoma, and lung adenocarcinoma, with IC50 values ranging from 0.05 to 2.14 Unit/mL [2]. |
In vivo | L-Methionine γ-lyase (Methionine lyase), administered through subcutaneous injection at a dose of 3 × 10^10 CFU over a period of four days, attenuated periodontitis induced by P. gingivalis in BALB/c mice [3]. |
Synonyms | Methionine lyase |
Molecular Weight | N/A |
CAS No. | 42616-25-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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L-Methionine γ-lyase 42616-25-1 Methionine lyase inhibitor inhibit