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Pentabromopseudilin
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Catalog No. T78585Cas No. 10245-81-5
Pentabromopseudilin (PBrP), a marine antibiotic derived from Pseudomonas bromoutilis and Alteromonas luteoviolaceus, demonstrates antimicrobial, antitumor, and phytotoxic properties. It acts as a reversible, allosteric inhibitor of myosin Va (MyoVa) and robustly inhibits transforming growth factor-β (TGF-β) activity. PBrP is utilized in researching fibrotic diseases and cancer [1].
Pentabromopseudilin
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Catalog No. T78585Cas No. 10245-81-5
Pentabromopseudilin (PBrP), a marine antibiotic derived from Pseudomonas bromoutilis and Alteromonas luteoviolaceus, demonstrates antimicrobial, antitumor, and phytotoxic properties. It acts as a reversible, allosteric inhibitor of myosin Va (MyoVa) and robustly inhibits transforming growth factor-β (TGF-β) activity. PBrP is utilized in researching fibrotic diseases and cancer [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $1,370 | 8-10 weeks | 8-10 weeks | |
| 50 mg | $2,780 | 8-10 weeks | 8-10 weeks | |
| 100 mg | $3,700 | 8-10 weeks | 8-10 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Pentabromopseudilin (PBrP), a marine antibiotic derived from Pseudomonas bromoutilis and Alteromonas luteoviolaceus, demonstrates antimicrobial, antitumor, and phytotoxic properties. It acts as a reversible, allosteric inhibitor of myosin Va (MyoVa) and robustly inhibits transforming growth factor-β (TGF-β) activity. PBrP is utilized in researching fibrotic diseases and cancer [1]. |
| In vitro | Pentabromopseudilin (PBrP) at concentrations of 0.01-1 μM for 6 hours inhibited TGF-β-induced phosphorylation and nuclear translocation of Smad proteins [1]. Additionally, at 0.5 μM for 6 hours, PBrP suppressed the transcriptional response stimulated by TGF-β [1]. Furthermore, PBrP across a range of 0-1 μM for 6 hours impeded TGF-β-induced epithelial-mesenchymal transition (EMT) in A549 cells [1]. At a specific dose of 0.2 μM for 20 hours, PBrP obstructed cell migration prompted by TGF-β [1]. PBrP at 0.01-1 μM for 6 hours blocked TGF-β signaling by enhancing the degradation of TβRII [1]. At a concentration of 0.5μM and at time intervals of 0, 1, and 3 hours, PBrP disrupted TGF-β signaling by promoting TβRII degradation through caveolae-dependent endocytosis [1]. |
| Molecular Weight | 553.66 |
| Formula | C10H4Br5NO |
| Cas No. | 10245-81-5 |
| Smiles | OC1=C(C=C(Br)C=C1Br)C2=C(Br)C(Br)=C(Br)N2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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