Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MAO-B-IN-22 (compound 6h) represents a powerful MAO-B inhibitor, boasting an IC50 value of 0.014 μM, and exhibits high antioxidant activity alongside effective metal-chelating properties. It also demonstrates adequate BBB permeability and notable neuroprotective effects [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | MAO-B-IN-22 (compound 6h) represents a powerful MAO-B inhibitor, boasting an IC50 value of 0.014 μM, and exhibits high antioxidant activity alongside effective metal-chelating properties. It also demonstrates adequate BBB permeability and notable neuroprotective effects [1]. |
In vitro | MAO-B-IN-22 (compound 6h) demonstrated dose-dependent protection against hydrogen peroxide-induced oxidative damage, enhancing cell viability at concentrations ranging from 2.5 to 50 μM over 24 hours [1]. Additionally, at lower concentrations of 0.5 to 10 μM and the same duration, it dose-dependently reduced LPS-induced NO production, indicating anti-neuroinflammatory activity [1]. |
In vivo | MAO-B-IN-22 (compound 6h) (53.5 mg/kg, administered via oral gavage once daily for three weeks) can alleviate motor impairments in mice by inhibiting MAO-B, increasing dopaminergic neurotransmitter levels, and reducing oxidative damage caused by reactive oxygen species (ROS). It also has the potential to mitigate motor dysfunction in mice treated with MPTP and may improve symptoms of Parkinson's disease (PD) in vivo [1]. |
Molecular Weight | 323.36 |
Formula | C20H18FNO2 |
CAS No. | 2902600-76-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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MAO-B-IN-22 2902600-76-2 Neuroscience Monoamine Oxidase inhibitor inhibit