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Chikusetsusaponin IVa

Name: Chikusetsusaponin IVa
Brand: TargetMol
SKU: T3863
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3863Cas No. 51415-02-2

Alias Calenduloside F

Chikusetsusaponin IVa (Calenduloside F) is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may be developed into a new potential for therapeutic agent used in T2DM patients.

Chikusetsusaponin IVa

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Purity: 99.64%

Catalog No. T3863Alias Calenduloside FCas No. 51415-02-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
5 mg	$88	In Stock	In Stock
10 mg	$130	In Stock	In Stock
25 mg	$220	In Stock	In Stock
50 mg	$326	In Stock	In Stock
100 mg	$463	-	In Stock
200 mg	$652	-	In Stock
1 mL x 10 mM (in DMSO)	$113	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.64%

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Chikusetsusaponin IVa AI Summary

Chikusetsusaponin IVa exhibits multiple biological activities including cytotoxic, anti-inflammatory, and immune-modulating effects. It shows cytotoxic activity against human HL60 and HCT116 cells with IC50 values of 76230.0 nM and 78110.0 nM respectively in MTT assays. Additionally, it inhibits the generation of superoxide anion in human neutrophils stimulated by fMLP/CB with an IC50 of 2880.0 nM and suppresses elastase release with an IC50 of 4760.0 nM. The compound also demonstrates significant anti-inflammatory activity by inhibiting inducible nitric oxide synthase (iNOS) in mouse RAW264.7 cells, showing 92.8% inhibition at a concentration of 30 µM after 1 hour of preincubation followed by lipopolysaccharide (LPS) stimulation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Chikusetsusaponin IVa (Calenduloside F) is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may be developed into a new potential for therapeutic agent used in T2DM patients.
Synonyms	Calenduloside F

Chemical Properties

Molecular Weight	794.97
Formula	C₄₂H₆₆O₁₄
Cas No.	51415-02-2
Smiles	CC1(C)CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(=O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Relative Density.	1.37 g/cm3 at 20℃

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (75.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2579 mL	6.2895 mL	12.5791 mL	62.8955 mL
5 mM	0.2516 mL	1.2579 mL	2.5158 mL	12.5791 mL
10 mM	0.1258 mL	0.6290 mL	1.2579 mL	6.2895 mL
20 mM	0.0629 mL	0.3145 mL	0.6290 mL	3.1448 mL
50 mM	0.0252 mL	0.1258 mL	0.2516 mL	1.2579 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc