Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BET-IN-14 is a pan BET inhibitor with an IC50 of 5.35 nM, demonstrating oral activity and anticancer properties [1].
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Description | BET-IN-14 is a pan BET inhibitor with an IC50 of 5.35 nM, demonstrating oral activity and anticancer properties [1]. |
In vitro | BET-IN-14 (Compound 171) demonstrated antitumor activity across multiple cancer cell lines (average IC50: 174.7 nM), particularly in MM.1S, Ty-82, MV-4-11, and KG-1 cells [1] over a period of 72 hours. |
In vivo | BET-IN-14 (Compound 171), administered orally at doses of 50 and 100 mg/kg once daily, inhibited tumor growth in mice with MV-4-11 xenografts [1]. |
Molecular Weight | 527.66 |
Formula | C30H37N7O2 |
CAS No. | 2243669-93-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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BET-IN-14 2243669-93-2 Chromatin/Epigenetic Epigenetic Reader Domain inhibitor inhibit