Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. It induces apoptosis in HuT-78 cutaneous T cell lymphoma cells in a concentration-dependent manner and disrupts the mitochondrial membrane potential when used at a concentration of 200 μM. Expression of ganglioside GD3 in GD3-negative SK-MEL-28-N1 malignant melanoma cells increases both cell proliferation and invasion in vitro. Ganglioside GD3-deficient adult mice exhibit progressive loss of the neural stem cell (NSC) pool and impaired neurogenesis. Ganglioside GD3 mixture contains ganglioside GD3 molecular species with C18:1 and C20:1 sphingoid backbones.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 35 days | $ 2,580.00 |
Description | Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. It induces apoptosis in HuT-78 cutaneous T cell lymphoma cells in a concentration-dependent manner and disrupts the mitochondrial membrane potential when used at a concentration of 200 μM. Expression of ganglioside GD3 in GD3-negative SK-MEL-28-N1 malignant melanoma cells increases both cell proliferation and invasion in vitro. Ganglioside GD3-deficient adult mice exhibit progressive loss of the neural stem cell (NSC) pool and impaired neurogenesis. Ganglioside GD3 mixture contains ganglioside GD3 molecular species with C18:1 and C20:1 sphingoid backbones. |
Molecular Weight | 1516.726 |
Formula | C70H123N3Na2O29 |
CAS No. | 62010-37-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Chloroform:Methanol (1:1): Soluble
H2O: Soluble
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Ganglioside GD3 Mixture (sodium salt) 62010-37-1 Ganglioside GD-3 Mixture (sodium salt) Ganglioside GD3 Mixture inhibitor inhibit