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PROTAC RIPK degrader-6

Name: PROTAC RIPK degrader-6
Brand: TargetMol
SKU: T36243
Rating: 4.5 (1 reviews)

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Catalog No. T36243Cas No. 2089205-64-9

PROTAC RIPK degrader-6 (example 1) is a PROTAC engineered for RIP Kinase degradation, comprising a RIP2 kinase inhibitor linked to a cereblon binder[1].

PROTAC RIPK degrader-6

😃Good

Catalog No. T36243Cas No. 2089205-64-9

PROTAC RIPK degrader-6 (example 1) is a PROTAC engineered for RIP Kinase degradation, comprising a RIP2 kinase inhibitor linked to a cereblon binder[1].

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$898	Inquiry	Inquiry
10 mg	$1,285	Inquiry	Inquiry
25 mg	$2,100	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$770	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	PROTAC RIPK degrader-6 (example 1) is a PROTAC engineered for RIP Kinase degradation, comprising a RIP2 kinase inhibitor linked to a cereblon binder[1].
In vitro	PROTACs facilitate the targeted degradation of proteins and polypeptides by binding to cereblon at one end and the target protein (RIP2 kinase) at the other, thereby bringing the target protein close to the E3-Ligase. This interaction forms a ternary complex that results in the polyubiquitination and subsequent degradation of the target protein[1].

Chemical Properties

Molecular Weight	889.01
Formula	C₄₃H₄₈N₆O₁₁S₂
Cas No.	2089205-64-9
Smiles	CC(C)(C)S(=O)(=O)c1cc2c(Nc3ccc4scnc4c3)ccnc2cc1OCCOCCOCCOCCOCC(=O)Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (112.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (5.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1248 mL	5.6242 mL	11.2485 mL	56.2423 mL
5 mM	0.2250 mL	1.1248 mL	2.2497 mL	11.2485 mL
10 mM	0.1125 mL	0.5624 mL	1.1248 mL	5.6242 mL
20 mM	0.0562 mL	0.2812 mL	0.5624 mL	2.8121 mL
50 mM	0.0225 mL	0.1125 mL	0.2250 mL	1.1248 mL
100 mM	0.0112 mL	0.0562 mL	0.1125 mL	0.5624 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc