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2-Furoyl-LIGRLO-amide TFA

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Catalog No. T75905Cas No. 2468029-34-5

2-Furoyl-LIGRLO-amide TFA is a potent, selective agonist of the proteinase-activated receptor 2 (PAR2), with a pD2 value of 7.0 [1] [2].

2-Furoyl-LIGRLO-amide TFA
Other Forms of 2-Furoyl-LIGRLO-amide TFA:

2-Furoyl-LIGRLO-amide TFA

😃Good
Catalog No. T75905Cas No. 2468029-34-5
2-Furoyl-LIGRLO-amide TFA is a potent, selective agonist of the proteinase-activated receptor 2 (PAR2), with a pD2 value of 7.0 [1] [2].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mgInquiry8-10 weeks8-10 weeks
50 mgInquiry8-10 weeks8-10 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
2-Furoyl-LIGRLO-amide TFA is a potent, selective agonist of the proteinase-activated receptor 2 (PAR2), with a pD2 value of 7.0 [1] [2].
In vitro
2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) demonstrates equivalent efficacy and exhibits 10 to 25-fold greater potency than SLIGRLNH2 in elevating intracellular calcium levels in human and rat cells expressing PAR2, respectively [1]. In tissue, it surpasses SLIGRL-NH2 by 10 to 300 times in causing arterial vasodilation and hyperpolarization. Unlike trans-cinnamoyl-LIGRLO-NH2, it does not induce significant non-PAR2-mediated contraction in mouse femoral arteries [1].
In vivo
When administered intradermally at the nape of the neck as a pre-injection at a dose of 10 μg, Furoyl-LIGRLO-amide TFA reduces scratching responses to 2-Furoyl-LIGRLO-amide in Trpv3 -/- mice, but not to histamine. In wild-type (WT) mice, however, the compound significantly decreases scratch behavior [3].
Chemical Properties
Molecular Weight891.98
FormulaC38H64F3N11O10
Cas No.2468029-34-5
Smiles#N/A
Sequence{Fur-2-oyl}-Leu-Ile-Gly-Arg-Leu-{Orn}-NH2
Sequence Short{Fur-2-oyl}-LIGRL-{Orn}
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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