Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a dissociation constant (K D) of 3.65 pM, exhibiting chondroprotective and anti-inflammatory properties. It has the capability to bind to albumin, which prolongs its plasma half-life [1] [2] [3].
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Description | Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a dissociation constant (K D) of 3.65 pM, exhibiting chondroprotective and anti-inflammatory properties. It has the capability to bind to albumin, which prolongs its plasma half-life [1] [2] [3]. |
In vitro | Isecarosmab selectively binds to ADAMTS-5 without interaction with ADAMTS-1, ADAMTS-4, or ADAMTS-15 [1]. |
In vivo | Isecarosmab, administered subcutaneously at doses ranging from 0.1 to 10 mg/kg every three days, mitigates medial cartilage degeneration in mice following medial meniscectomy (DMM) [1]. |
Synonyms | M-6495 |
Molecular Weight | N/A |
CAS No. | 2254082-79-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Isecarosmab 2254082-79-4 M-6495 inhibitor inhibit