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Isecarosmab (Alias: M-6495, M6495)
Catalog No. T82045 Copy Product Info
Purity: 95%
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Isecarosmab (M6495) is a monoclonal antibody targeting ADAMTS-5, capable of protecting cartilage and inhibiting ADAMTS-5-mediated degradation of aggrecan, for use in osteoarthritis (OA) research.
Isecarosmab
Copy Product Info🥰Excellent
Catalog No. T82045
Alias M-6495, M6495
Isecarosmab (M6495) is a monoclonal antibody targeting ADAMTS-5, capable of protecting cartilage and inhibiting ADAMTS-5-mediated degradation of aggrecan, for use in osteoarthritis (OA) research.
Isecarosmab
Cas No. 2254082-79-4
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $289 | - | In Stock | |
| 5 mg | $745 | - | In Stock | |
| 10 mg | $1,180 | - | In Stock | |
| 25 mg | $1,770 | - | In Stock | |
| 50 mg | $2,380 | - | In Stock |
In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.0% (SDS-PAGE); 96.7% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Isecarosmab (M6495) is a monoclonal antibody targeting ADAMTS-5, capable of protecting cartilage and inhibiting ADAMTS-5-mediated degradation of aggrecan, for use in osteoarthritis (OA) research. |
| In vitro | In bovine and human osteoarthritis (OA) cartilage samples, Isecarosmab (1-100 nM, 5 days) dose-dependently inhibited the significant release of huARGS and exAGNxI induced by O+T, as well as the release of GAG induced by IL-1α [1]. |
| In vivo | Isecarosmab significantly improved medial cartilage degeneration in mice with destabilization of the medial meniscus (DMM) when administered subcutaneously at doses of 0.1-10 mg/kg every three days [1]. |
| Synonyms | M-6495, M6495 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | ALB & ADAMTSL5 |
| Molecular Weight | 28.05 kDa |
| Cas No. | 2254082-79-4 |
| Isotype | VH-VH' |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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