Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

AUTAC2

Name: AUTAC2
Brand: TargetMol
SKU: T74026
Rating: 4.5 (1 reviews)

Copy Product Info

😃Good

Catalog No. T74026Cas No. 2241669-08-7

Alias AUTAC 2

AUTAC2 is an FKBP12-targeting autophagy-mediated degrader that incorporates both an FBnG (p-fluorobenzyl guanine) moiety and an SLF moiety, with SLF binding noncovalently to FKBP12, AUTAC2 is utilized in targeted protein degradation research to explore selective autophagic clearance, intracellular quality control mechanisms, and novel degrader design strategies.

AUTAC2

Copy Product Info

😃Good

Catalog No. T74026Alias AUTAC 2Cas No. 2241669-08-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	AUTAC2 is an FKBP12-targeting autophagy-mediated degrader that incorporates both an FBnG (p-fluorobenzyl guanine) moiety and an SLF moiety, with SLF binding noncovalently to FKBP12, AUTAC2 is utilized in targeted protein degradation research to explore selective autophagic clearance, intracellular quality control mechanisms, and novel degrader design strategies.
In vitro	In HeLa cells, treatment with AUTAC2 (10 μM) promoted the K63-linked polyubiquitination of endogenous FKBP12 [1].
Synonyms	AUTAC 2

Chemical Properties

Molecular Weight	1229.42
Formula	C₆₁H₈₁FN₁₀O₁₄S
Cas No.	2241669-08-7
Smiles	C(N1C2=C(N=C1SC[C@@H](C(NCCCOCCOCCOCCCNC(CCC(NC3=CC([C@H](OC(=O)C4N(C(C(C(CC)(C)C)=O)=O)CCCC4)CCC5=CC(OC)=C(OC)C=C5)=CC=C3)=O)=O)=O)NC(C)=O)C(=O)N=C(N)N2)C6=CC=C(F)C=C6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (65.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8134 mL	4.0670 mL	8.1339 mL	40.6696 mL
5 mM	0.1627 mL	0.8134 mL	1.6268 mL	8.1339 mL
10 mM	0.0813 mL	0.4067 mL	0.8134 mL	4.0670 mL
20 mM	0.0407 mL	0.2033 mL	0.4067 mL	2.0335 mL
50 mM	0.0163 mL	0.0813 mL	0.1627 mL	0.8134 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

AUTAC2

AUTAC2

Featured Recommendations

Resource Download

Product Introduction

Calculator

In Vivo Formulation Calculator (Clear solution)

Dose Conversion

Tech Support