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AUTAC2

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Catalog No. T74026Cas No. 2241669-08-7
Alias AUTAC 2

AUTAC2 is an FKBP12-targeting autophagy-mediated degrader that incorporates both an FBnG (p-fluorobenzyl guanine) moiety and an SLF moiety, with SLF binding noncovalently to FKBP12, AUTAC2 is utilized in targeted protein degradation research to explore selective autophagic clearance, intracellular quality control mechanisms, and novel degrader design strategies.

AUTAC2

AUTAC2

😃Good
Catalog No. T74026Alias AUTAC 2Cas No. 2241669-08-7
AUTAC2 is an FKBP12-targeting autophagy-mediated degrader that incorporates both an FBnG (p-fluorobenzyl guanine) moiety and an SLF moiety, with SLF binding noncovalently to FKBP12, AUTAC2 is utilized in targeted protein degradation research to explore selective autophagic clearance, intracellular quality control mechanisms, and novel degrader design strategies.
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
AUTAC2 is an FKBP12-targeting autophagy-mediated degrader that incorporates both an FBnG (p-fluorobenzyl guanine) moiety and an SLF moiety, with SLF binding noncovalently to FKBP12, AUTAC2 is utilized in targeted protein degradation research to explore selective autophagic clearance, intracellular quality control mechanisms, and novel degrader design strategies.
In vitro
In HeLa cells, treatment with AUTAC2 (10 μM) promoted the K63-linked polyubiquitination of endogenous FKBP12 [1].
SynonymsAUTAC 2
Chemical Properties
Molecular Weight1229.42
FormulaC61H81FN10O14S
Cas No.2241669-08-7
SmilesC(N1C2=C(N=C1SC[C@@H](C(NCCCOCCOCCOCCCNC(CCC(NC3=CC([C@H](OC(=O)C4N(C(C(C(CC)(C)C)=O)=O)CCCC4)CCC5=CC(OC)=C(OC)C=C5)=CC=C3)=O)=O)=O)NC(C)=O)C(=O)N=C(N)N2)C6=CC=C(F)C=C6
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (65.07 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.8134 mL4.0670 mL8.1339 mL40.6696 mL
5 mM0.1627 mL0.8134 mL1.6268 mL8.1339 mL
10 mM0.0813 mL0.4067 mL0.8134 mL4.0670 mL
20 mM0.0407 mL0.2033 mL0.4067 mL2.0335 mL
50 mM0.0163 mL0.0813 mL0.1627 mL0.8134 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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2 Enter the in vivo formulation:
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