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Ganitumab
(Synonyms: AMG 479) Copy Product Info
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Synonyms: AMG 479
Catalog No. T76810 Copy Product Info
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Ganitumab (AMG 479) is a highly potent monoclonal antibody targeting the type 1 insulin-like growth factor receptor (IGF1R). Recognized for binding IGF1R at low concentrations with a KD value of 0.22 nM, Ganitumab inhibits IGF1R interactions with IGF1 and IGF2 in mice, making it useful for cancer research.
Cas No. 905703-97-1
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $289 | In Stock | In Stock | |
| 5 mg | $755 | In Stock | In Stock | |
| 10 mg | $1,180 | - | In Stock | |
| 25 mg | $1,780 | - | In Stock | |
| 50 mg | $2,390 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:100% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
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Chemical Properties
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| Description | Ganitumab (AMG 479) is a highly potent monoclonal antibody targeting the type 1 insulin-like growth factor receptor (IGF1R). Recognized for binding IGF1R at low concentrations with a KD value of 0.22 nM, Ganitumab inhibits IGF1R interactions with IGF1 and IGF2 in mice, making it useful for cancer research. |
| In vitro | Ganitumab (AMG 479; 0.032-500 nM; 10 minutes; cT26 cells) binds to mIGF1R, inhibiting its activation mediated by IGF1 and IGF2[1]. |
| In vivo | In naive and tumor-bearing mice, ganitumab (AMG 479; 1 mg/dose; i.p.) inhibited IGF1-induced activation of mIGF1R in mouse lung[1]. In female thymusless nude mice, ganitumab (300 μg/dose; i.p.) reduced peripheral blood neutrophils[1]. In male athymic nude mice, ganitumab (300 μg/dose; i.p.) resulted in impaired glucose tolerance and increased serum mGH, mIGF1, and mIGFBP3[1]. |
| Endotoxin | <1.0 EU/mg |
| Synonyms | AMG 479 |
| Reactivity | Human |
| Verified Activity | Immobilized Human IGF1R/CD221 Protein (His) (TMPY-00834) at 1 μg/mL (100 μL/well) can bind Ganitumab. The EC50 is 22.38 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | IGF1-R/IGFR1/CD221 |
| Molecular Weight | 145.70 kDa |
| Cas No. | 905703-97-1 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Ganitumab chemical structure | Ganitumab in vivo | Ganitumab in vitro | Ganitumab molecular weight
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