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Ganitumab

Catalog No. T76810 CAS 905703-97-1

Synonyms: AMG 479

Ganitumab (AMG 479) is a highly potent monoclonal antibody to type 1 insulin-like growth factor receptor (IGF1R). Ganitumab is recognized to bind to IGF1R at low concentration with KD value of 0.22 nM. Ganitumab can inhibit the interaction of IGF1R with IGF1 and IGF2 in mice. Ganitumab can be used to study cancer.

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Ganitumab

Ganitumab, CAS 905703-97-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 289.00
5 mg	In stock	$ 755.00
10 mg	In stock	$ 1,180.00
25 mg	In stock	$ 1,780.00
50 mg	In stock	$ 2,390.00

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Biological Description

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Description	Ganitumab (AMG 479) is a highly potent monoclonal antibody to type 1 insulin-like growth factor receptor (IGF1R). Ganitumab is recognized to bind to IGF1R at low concentration with KD value of 0.22 nM. Ganitumab can inhibit the interaction of IGF1R with IGF1 and IGF2 in mice. Ganitumab can be used to study cancer.
In vitro	Ganitumab (AMG 479; 0.032-500 nM; 10 minutes; cT26 cells) binds to mIGF1R and inhibits the activation of mIGF1R mediated by IGF1 and IGF2[1].
In vivo	In naive and tumor-bearing mice, ganitumab (AMG 479; 1 mg/dose; i.p.) inhibited IGF1-induced activation of mIGF1R in mouse lung[1]. In female thymusless nude mice, ganitumab (300 μg/dose; i.p.) reduced peripheral blood neutrophils[1]. In male athymic nude mice, ganitumab (300 μg/dose; i.p.) resulted in impaired glucose tolerance and increased serum mGH, mIGF1, and mIGFBP3[1].

Synonyms	AMG 479
Molecular Weight	N/A
CAS No.	905703-97-1

Storage

store at low temperature

store at -80°C

References and Literature

1. Moody G, et, al. IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice. J Endocrinol. 2014 Mar 17;221(1):145-55.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ganitumab 905703-97-1 Tyrosine Kinase/Adaptors IGF-1R AMG-479 AMG 479 AMG479 inhibitor inhibit

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