Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-density lipoprotein (oxLDL) and high glucose (HG). It also protects vascular endothelial cells (VEC) from oxLDL and HG-induced injury, offering potential therapeutic benefits for the prevention and treatment of atherosclerosis [1].
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50 mg | Inquiry | Inquiry |
Description | Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-density lipoprotein (oxLDL) and high glucose (HG). It also protects vascular endothelial cells (VEC) from oxLDL and HG-induced injury, offering potential therapeutic benefits for the prevention and treatment of atherosclerosis [1]. |
In vitro | Nrf2 activator-9 (compound D-36) at concentrations of 5 μM and 10 μM applied for 6 hours reversed the apoptosis of HUVECs induced by 50 μg/mL oxLDL [1]. Additionally, Nrf2 activator-9, administered at the same concentrations for 6 and 24 hours, promoted the nuclear translocation of Nrf2 and activated its antioxidative pathway, thereby conferring a protective effect on HUVECs [1]. |
Molecular Weight | 473.52 |
Formula | C26H27N5O4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Nrf2 activator-9 inhibitor inhibit