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m7GTP sodium (7-Methyl-guanosine-5'-triphosphate sodium) is a structural analog of the mRNA cap that inhibits protein synthesis in vitro by binding to eIF4E (eukaryotic translation initiation factor), and is commonly used to study protein synthesis involving mRNA.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $118 | In Stock |
Description | m7GTP sodium (7-Methyl-guanosine-5'-triphosphate sodium) is a structural analog of the mRNA cap that inhibits protein synthesis in vitro by binding to eIF4E (eukaryotic translation initiation factor), and is commonly used to study protein synthesis involving mRNA. |
In vitro | m7GTP sodium acts as a competitive inhibitor of the eukaryotic translation initiation factor eIF4E. In various in vitro assays, m7GTP sodium is commonly used to block cap-dependent translation. For example, at 200 μM, m7GTP sodium effectively inhibits the binding of eIF4E to capped mRNAs in cell-free systems or lysates, impairing translation initiation[1]. |
Alias | 7-Methyl-guanosine-5'-triphosphate sodium |
Molecular Weight | C11H18N5O14P3.xNa |
Formula | C11H18N5O14P3.xNa |
Smiles | CN1C=[N+](C2=C1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])O)O.[Na+] xNa |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | H2O: 200 mg/mL, Sonication is recommended. |
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