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YW3-56 (hydrochloride) (technical grade)

Catalog No. T36108 CAS 2309756-20-3

Synonyms: YW3-56 (hydrochloride) (technical grade)

YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 μM) in a p53-dependent mannerviainduction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.2

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YW3-56 (hydrochloride) (technical grade) Chemical Structure

YW3-56 (hydrochloride) (technical grade), CAS 2309756-20-3

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 2,420.00
50 mg	10-14 weeks	$ 3,180.00
100 mg	10-14 weeks	$ 4,300.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	YW3-56 (hydrochloride) (technical grade)
Molecular Weight	530.49
Formula	C27H33Cl2N5O2
CAS No.	2309756-20-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Methanol: 10 mg/mL

References and Literature

1. Wang, Y., Li, P., Wang, S., et al.Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex 1 activityThe Journal of Biological Chemisty287(31)25941-25952(2012) 2. Wang, S., Chen, X.A., Hu, J., et al.ATF4 gene network mediates cellular response to the anticancer PAD inhibitor YW3-56 in triple-negative breast cancer cellsMol. Cancer Ther.14(4)877-888(2015)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

YW3-56 (hydrochloride) (technical grade) 2309756-20-3 YW3 56 (hydrochloride) (technical grade) YW356 (hydrochloride) (technical grade) technical grade YW3-56 (hydrochloride) YW-3-56 (hydrochloride) (technical grade) inhibitor inhibit

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