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YW3-56 (hydrochloride) (technical grade)

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Catalog No. T36108Cas No. 2309756-20-3
Alias YW3-56 (hydrochloride) (technical grade)

YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 μM) in a p53-dependent mannerviainduction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.2

YW3-56 (hydrochloride) (technical grade)
Other Forms of YW3-56 (hydrochloride) (technical grade):

YW3-56 (hydrochloride) (technical grade)

😃Good
Catalog No. T36108Alias YW3-56 (hydrochloride) (technical grade)Cas No. 2309756-20-3
YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 μM) in a p53-dependent mannerviainduction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.2
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$2,42010-14 weeks10-14 weeks
50 mg$3,18010-14 weeks10-14 weeks
100 mg$4,30010-14 weeks10-14 weeks
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Expected start date of shipmentUSA Warehouse [1-2 days] Global Warehouse [5-7 days]
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Product Introduction

Bioactivity
Description
YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 μM) in a p53-dependent mannerviainduction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.2
SynonymsYW3-56 (hydrochloride) (technical grade)
Chemical Properties
Molecular Weight530.49
FormulaC27H33Cl2N5O2
Cas No.2309756-20-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Methanol: 10 mg/mL (18.85 mM), Sonication is recommended.
Solution Preparation Table
Methanol
1mg5mg10mg50mg
1 mM1.8850 mL9.4252 mL18.8505 mL94.2525 mL
5 mM0.3770 mL1.8850 mL3.7701 mL18.8505 mL
10 mM0.1885 mL0.9425 mL1.8850 mL9.4252 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

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