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GaTx2

😃Good
Catalog No. TP2027Cas No. 194665-85-5

Very high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC, CaCC and KV1.2.

GaTx2

GaTx2

😃Good
Catalog No. TP2027Cas No. 194665-85-5
Very high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC, CaCC and KV1.2.
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10 mg$2,631InquiryInquiry
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Very high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC, CaCC and KV1.2.
Chemical Properties
Molecular Weight3192.54
FormulaC125H199N39O47S6
Cas No.194665-85-5
SmilesO=C1N2[C@](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC3=CN=CN3)C(=O)N[C@@]4(C(=O)N[C@@H](CO)C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@]5(CSSC[C@H](NC([C@@H](NC([C@H](C(C)C)N)=O)CO)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@]1(CSSC[C@](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC5=O)(C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(N[C@H](C(=O)N6[C@H](C(N[C@@H]([C@H](CC)C)C(O)=O)=O)CCC6)CCC(O)=O)=O)CSSC4)[H])[H])[H])[H])[H])(CCC2)[H]
Relative Density.1.65 g/cm3 (Predicted)
Sequence ShortVSCEDCPDHCSTQKARAKCDNDKCVCEPI (Disulfide bridge:Cys3-Cys19;Cys6-Cys24;Cys10-Cys26)
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 1 mg/mL (0.31 mM), Sonication is recommended.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

GaTx-2GaTx2
Related Tags: buy GaTx2 | purchase GaTx2 | GaTx2 cost | order GaTx2 | GaTx2 chemical structure | GaTx2 formula | GaTx2 molecular weight
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