Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

5-Chlorouracil

Name: 5-Chlorouracil
Brand: TargetMol
SKU: T36235
Rating: 4.5 (1 reviews)

Copy Product Info

😃Good

Catalog No. T36235Cas No. 1820-81-1

5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil .

5-Chlorouracil

Copy Product Info

😃Good

Catalog No. T36235Cas No. 1820-81-1

5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil .

Pack Size	Price	USA Warehouse	Global Warehouse
5 g	$133	35 days	35 days
10 g	$236	35 days	35 days
25 g	$420	35 days	35 days
50 g	$772	35 days	35 days

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description

5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil .

In vivo

In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic. Uracil is chlorinated at the 5 position in a cell-free myeloperoxidase, peroxide, and chloride system in which hypochlorous acid is formed. 5-Chlorouracil has been found in human neutrophils stimulated with phorbol 12-myristate 13-acetate in vitro and in inflammatory human exudate isolated from sites of superficial infection. Levels of 5-chlorouracil are increased in exudate isolated from the site of inflammation in a rat model of carrageenan-induced inflammation and in patient-derived human atherosclerotic aortic tissue.

Chemical Properties

Molecular Weight	146.53
Formula	C₄H₃ClN₂O₂
Cas No.	1820-81-1
Smiles	Clc1c[nH]c(=O)[nH]c1=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

PBS (pH 7.2): 60 mg/mL (409.47 mM), Sonication is recommended.

DMF: 8 mg/mL (54.6 mM), Sonication is recommended.

DMSO: 0.8 mg/mL (5.46 mM), Sonication is recommended.

Ethanol: 53 mg/mL (361.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO/DMF/Ethanol/PBS (pH 7.2)

	1mg	5mg	10mg	50mg
1 mM	6.8245 mL	34.1227 mL	68.2454 mL	341.2271 mL
5 mM	1.3649 mL	6.8245 mL	13.6491 mL	68.2454 mL

DMF/Ethanol/PBS (pH 7.2)

	1mg	5mg	10mg	50mg
10 mM	0.6825 mL	3.4123 mL	6.8245 mL	34.1227 mL
20 mM	0.3412 mL	1.7061 mL	3.4123 mL	17.0614 mL
50 mM	0.1365 mL	0.6825 mL	1.3649 mL	6.8245 mL

Ethanol/PBS (pH 7.2)

	1mg	5mg	10mg	50mg
100 mM	0.0682 mL	0.3412 mL	0.6825 mL	3.4123 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

5-Chlorouracil5Chlorouracil5 Chlorouracil