Powder: -20°C for 3 years | In solvent: -80°C for 1 year
5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil .
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 g | 35 days | $ 93.00 | |
10 g | 35 days | $ 163.00 | |
25 g | 35 days | $ 290.00 | |
50 g | 35 days | $ 533.00 |
Description | 5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil . |
In vivo | In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic. Uracil is chlorinated at the 5 position in a cell-free myeloperoxidase, peroxide, and chloride system in which hypochlorous acid is formed. 5-Chlorouracil has been found in human neutrophils stimulated with phorbol 12-myristate 13-acetate in vitro and in inflammatory human exudate isolated from sites of superficial infection. Levels of 5-chlorouracil are increased in exudate isolated from the site of inflammation in a rat model of carrageenan-induced inflammation and in patient-derived human atherosclerotic aortic tissue. |
Molecular Weight | 146.53 |
Formula | C4H3ClN2O2 |
CAS No. | 1820-81-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PBS (pH 7.2): 60 mg/mL
DMF: 8 mg/mL
DMSO: 0.8 mg/mL
Ethanol: 53 mg/mL
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
5-Chlorouracil 1820-81-1 5 Chlorouracil 5Chlorouracil inhibitor inhibit