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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | Inquiry | Backorder | |
100 mg | Inquiry | Backorder |
Description | TRV056 is a Gq-biased agonist of the angiotensin II type 1 receptor (AT1R), demonstrating efficacy in stimulating Gq-mediated cellular signaling. It can serve as a foundation for the development of Gq-biased AT1R agonists. |
In vitro | TRV056 is a "gain-of-function" ligand exhibiting over tenfold stronger allosteric coupling to Gq compared to Angiotensin II (AngII), thereby more effectively stimulating Gq-mediated cellular signaling, such as IP1 generation. As a Gq-biased AT1R agonist, it surpasses the endogenous ligand AngII in both efficacy of stimulating Gq-mediated signaling and in enhancing Gq coupling[1]. |
Alias | TRV056 |
Molecular Weight | 1103.249 |
Formula | C52H74N14O13 |
Cas No. | 812644-79-4 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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