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TRV056

TRV056
TRV056 is a Gq-biased agonist of the angiotensin II type 1 receptor (AT1R), demonstrating efficacy in stimulating Gq-mediated cellular signaling. It can serve as a foundation for the development of Gq-biased AT1R agonists.
Catalog No. T40920Cas No. 812644-79-4

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TRV056

Catalog No. T40920Alias TRV056Cas No. 812644-79-4

TRV056 is a Gq-biased agonist of the angiotensin II type 1 receptor (AT1R), demonstrating efficacy in stimulating Gq-mediated cellular signaling. It can serve as a foundation for the development of Gq-biased AT1R agonists.
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Product Introduction

Bioactivity
Description
TRV056 is a Gq-biased agonist of the angiotensin II type 1 receptor (AT1R), demonstrating efficacy in stimulating Gq-mediated cellular signaling. It can serve as a foundation for the development of Gq-biased AT1R agonists.
In vitro
TRV056 is a "gain-of-function" ligand exhibiting over tenfold stronger allosteric coupling to Gq compared to Angiotensin II (AngII), thereby more effectively stimulating Gq-mediated cellular signaling, such as IP1 generation. As a Gq-biased AT1R agonist, it surpasses the endogenous ligand AngII in both efficacy of stimulating Gq-mediated signaling and in enhancing Gq coupling[1].
AliasTRV056
Chemical Properties
Molecular Weight1103.249
FormulaC52H74N14O13
Cas No.812644-79-4
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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