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S65487 sulfate

Catalog No. T40070 CAS 2416937-01-2

Synonyms: VOB560 sulfate

S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, demonstrates activity against BCL-2 mutations, including G101V and D103Y. It exhibits poor affinity for MCL-1, BFL-1, and BCL-XL. Additionally, S65487 sulfate induces apoptosis and possesses anticancer activities.

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S65487 sulfate, CAS 2416937-01-2

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10 mg	Inquiry	$ 581.00

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Description	S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, demonstrates activity against BCL-2 mutations, including G101V and D103Y. It exhibits poor affinity for MCL-1, BFL-1, and BCL-XL. Additionally, S65487 sulfate induces apoptosis and possesses anticancer activities.
In vitro	S65487 effectively targets the BH3 hydrophobic groove of BCL-2, leading to the induction of apoptosis across various hematological cancer cell lines. Additionally, it significantly inhibits cell proliferation, demonstrating potency with IC50 values within the low nanomolar range[1].
In vivo	S65487 induces complete regression in BCL-2-dependent RS4;11 tumors in vivo after a single IV (intravenous) administration. Strong and persistent tumor regression in xenograft models of lymphoid malignancies in mouse and rat are observed at well tolerated doses following weekly IV administration of S65487 in combination with the MCL-1-specific inhibitor, S64315/MIK665[1].

Synonyms	VOB560 sulfate
Molecular Weight	815.34
Formula	C41H43ClN6O8S
CAS No.	2416937-01-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Arnaud Le Tiran, et al. Abstract 1276: Identification of S65487/VOB560 as a potent and selective intravenous 2nd-generation BCL-2 inhibitor active in wild-type and clinical mutants resistant to Venetoclax. Cancer Research. July 2021.

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Keywords

S65487 sulfate 2416937-01-2 VOB560 sulfate VOB-560 Sulfate VOB 560 Sulfate VOB560 Sulfate S-65487 sulfate S-65487 Sulfate S65487 Sulfate S 65487 Sulfate inhibitor inhibit

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