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S65487 sulfate
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Catalog No. T40070Cas No. 2416937-01-2
Alias VOB560 sulfate
S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, demonstrates activity against BCL-2 mutations, including G101V and D103Y, while showing poor affinity for MCL-1, BFL-1, and BCL-XL. It induces apoptosis and possesses anticancer activities.
S65487 sulfate
Copy Product Info😃Good
Catalog No. T40070Alias VOB560 sulfateCas No. 2416937-01-2
S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, demonstrates activity against BCL-2 mutations, including G101V and D103Y, while showing poor affinity for MCL-1, BFL-1, and BCL-XL. It induces apoptosis and possesses anticancer activities.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $581 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, demonstrates activity against BCL-2 mutations, including G101V and D103Y, while showing poor affinity for MCL-1, BFL-1, and BCL-XL. It induces apoptosis and possesses anticancer activities. |
| In vitro | S65487 effectively targets the BH3 hydrophobic groove of BCL-2, leading to the induction of apoptosis across various hematological cancer cell lines. Additionally, it significantly inhibits cell proliferation, demonstrating potency with IC50 values within the low nanomolar range[1]. |
| In vivo | S65487 induces complete regression in BCL-2-dependent RS4;11 tumors in vivo after a single IV (intravenous) administration. Strong and persistent tumor regression is observed in xenograft models of lymphoid malignancies in mouse and rat at well-tolerated doses following weekly IV administration of S65487 in combination with the MCL-1-specific inhibitor S64315/MIK665[1]. |
| Synonyms | VOB560 sulfate |
| Molecular Weight | 815.34 |
| Formula | C41H43ClN6O8S |
| Cas No. | 2416937-01-2 |
| Smiles | OS(O)(=O)=O.Cc1c(cc(C#N)n1C)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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