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IGF2BP1-IN-1
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Catalog No. T79724Cas No. 3029447-08-0
IGF2BP1-IN-1 is a highly efficient IGF2BP1 inhibitor with anti-cancer and anti-proliferative activities. It binds to insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and inhibits tumor growth. It can be used for research on lung cancer.
IGF2BP1-IN-1
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Purity: 99.94%
Catalog No. T79724Cas No. 3029447-08-0
IGF2BP1-IN-1 is a highly efficient IGF2BP1 inhibitor with anti-cancer and anti-proliferative activities. It binds to insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and inhibits tumor growth. It can be used for research on lung cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $299 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.94%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | IGF2BP1-IN-1 is a highly efficient IGF2BP1 inhibitor with anti-cancer and anti-proliferative activities. It binds to insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and inhibits tumor growth. It can be used for research on lung cancer. |
| Targets&IC50 | A549 cells:9 nM, HCT116 cells:34 nM, IGF2BP1 protein:2.88 nM (KD) |
| In vitro | IGF2BP1-IN-1 binds to IGF2BP1 protein with a KD value of 2.88 nM.IGF2BP1-IN-1 inhibited the proliferation of cancer cells with an IC50 of 9 nM for A549 cells and 34 nM for HCT116 cells. [1] |
| Molecular Weight | 777.87 |
| Formula | C42H52FN3O10 |
| Cas No. | 3029447-08-0 |
| Smiles | C[C@]12[C@]3([C@](C)([C@]4(C(=CC3)C(C)(C)C(=O)[C@@H](OC(CN5C(=O)N(C=N5)C6=CC=C(F)C=C6)=O)C4)[H])C(=O)C[C@]1(C)[C@@]([C@@](C(/C=C/C(OC(C)=O)(C)C)=O)(C)O)([C@H](O)C2)[H])[H] |
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (102.84 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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