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Gambogic amide
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Synonyms:
Catalog No. T86491 Copy Product Info
Purity: 97.91%
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Gambogic amide is a potent and selective agonist of tropomyosin receptor kinase A (TrkA) that promotes tyrosine phosphorylation and activates downstream signaling pathways including Akt and MAPK. Gambogic amide specifically binds to the cytoplasmic juxtamembrane domain of the TrkA receptor, thereby stimulating receptor dimerization and activation. Gambogic amide has been reported to prevent glutamate-induced neuronal cell death and demonstrates enhanced activity in a transient middle cerebral artery occlusion model of stroke. These biological properties support the utilization of Gambogic amide in research focused on neurodegenerative disorders, neuronal survival mechanisms, neurotrophic signaling pathways, and ischemic brain injury.
Cas No. 286935-60-2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $268 | - | In Stock | |
| 5 mg | $658 | - | In Stock | |
| 10 mg | $1,090 | - | In Stock | |
| 25 mg | $1,620 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:97.91%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Gambogic amide is a potent and selective agonist of tropomyosin receptor kinase A (TrkA) that promotes tyrosine phosphorylation and activates downstream signaling pathways including Akt and MAPK. Gambogic amide specifically binds to the cytoplasmic juxtamembrane domain of the TrkA receptor, thereby stimulating receptor dimerization and activation. Gambogic amide has been reported to prevent glutamate-induced neuronal cell death and demonstrates enhanced activity in a transient middle cerebral artery occlusion model of stroke. These biological properties support the utilization of Gambogic amide in research focused on neurodegenerative disorders, neuronal survival mechanisms, neurotrophic signaling pathways, and ischemic brain injury. |
| Molecular Weight | 627.77 |
| Formula | C38H45NO7 |
| Cas No. | 286935-60-2 |
| Smiles | C(/C=C(\C(N)=O)/C)[C@@]12[C@]34C(C(=O)C=5C(O3)=C(CC=C(C)C)C6=C(C5O)C=C[C@](CCC=C(C)C)(C)O6)=C[C@@](C1=O)(C[C@]4(C(C)(C)O2)[H])[H] |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Gambogic amide chemical structure | Gambogic amide formula | Gambogic amide molecular weight
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