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Larixol

Catalog No. T80653 CAS 1438-66-0

Synonyms: (+)-Larixol

Larixol acts as both an fMLP inhibitor and a modulator of various signaling pathways by inhibiting Src kinase, ERK1/2, p38, and AKT phosphorylation critical for immune responses. It disrupts the interaction between the βγ subunit of the Gi protein and downstream effectors linked to the fMLP receptor, thus abrogating fMLP-induced respiratory bursts. Additionally, larixol effectively reduces fMLP (0.1 μM)-triggered superoxide anion generation (IC50: 1.98 μM), cathepsin G secretion (IC50: 2.76 μM), and cellular chemotaxis, mitigating neutrophil hyperactivation and subsequent inflammation or tissue injury. Derivatives of larixol also demonstrate inhibitory activity on TRPC6 functional mutants associated with FSGS [1] [2].

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Larixol, CAS 1438-66-0

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	(+)-Larixol
Molecular Weight	306.48
Formula	C20H34O2
CAS No.	1438-66-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

Larixol 1438-66-0 Cytoskeletal Signaling PI3K/Akt/mTOR signaling Akt (+)-Larixol inhibitor inhibit

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