Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Procainamide

Name: Procainamide
Brand: TargetMol
SKU: T60322
Rating: 4.5 (1 reviews)

Copy Product Info

😃Good

Catalog No. T60322Cas No. 51-06-9

Alias Novocainamide, Biocoryl

Procainamide (Novocainamide) is a specific and potent DNA methyltransferase 1 (DNMT1) inhibitor and a Class 1A antiarrhythmic agent, with potential applications in cancer and arrhythmia research [1] [2].

Procainamide

Copy Product Info

😃Good

Purity: 99.92%

Catalog No. T60322Alias Novocainamide, BiocorylCas No. 51-06-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$33	6-8 weeks	6-8 weeks

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.92%

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Procainamide (Novocainamide) is a specific and potent DNA methyltransferase 1 (DNMT1) inhibitor and a Class 1A antiarrhythmic agent, with potential applications in cancer and arrhythmia research [1] [2].
In vitro	HCT116, HCT116 DNMT1−/−, and HCT116 DNMT3b−/− cells were treated with PBS, pH 7.4 or 0.5 mM procainamide for 96 h. Procainamide treatment of HCT116 DNMT3b−/− cells decreased m5dC content by 11.5%, but treatment of HCT116 DNMT1−/− cells did not decrease m5dC content. These results suggested that DNMT1 was the intracellular target of procainamide[1].
Synonyms	Novocainamide, Biocoryl

Chemical Properties

Molecular Weight	235.33
Formula	C₁₃H₂₁N₃O
Cas No.	51-06-9
Smiles	CCN(CC)CCNC(=O)c1ccc(N)cc1

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (191.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (4.25 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2494 mL	21.2468 mL	42.4935 mL	212.4676 mL
5 mM	0.8499 mL	4.2494 mL	8.4987 mL	42.4935 mL
10 mM	0.4249 mL	2.1247 mL	4.2494 mL	21.2468 mL
20 mM	0.2125 mL	1.0623 mL	2.1247 mL	10.6234 mL
50 mM	0.0850 mL	0.4249 mL	0.8499 mL	4.2494 mL
100 mM	0.0425 mL	0.2125 mL	0.4249 mL	2.1247 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc