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Procainamide

Name: Procainamide
Brand: TargetMol
SKU: T60322
Rating: 4.5 (1 reviews)

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Catalog No. T60322Cas No. 51-06-9

Alias Novocainamide, Biocoryl

Procainamide (Novocainamide) is a specific and potent DNA methyltransferase 1 (DNMT1) inhibitor and a Class 1A antiarrhythmic agent, with potential applications in cancer and arrhythmia research [1] [2].

Procainamide

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Purity: 99.92%

Catalog No. T60322Alias Novocainamide, BiocorylCas No. 51-06-9

Pack Size	Price	Availability	Quantity
200 mg	$33	6-8 weeks

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Purity:99.92%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Procainamide (Novocainamide) is a specific and potent DNA methyltransferase 1 (DNMT1) inhibitor and a Class 1A antiarrhythmic agent, with potential applications in cancer and arrhythmia research [1] [2].
In vitro	HCT116, HCT116 DNMT1−/−, and HCT116 DNMT3b−/− cells were treated with PBS, pH 7.4 or 0.5 mM procainamide for 96 h. Procainamide treatment of HCT116 DNMT3b−/− cells decreased m5dC content by 11.5%, but treatment of HCT116 DNMT1−/− cells did not decrease m5dC content. These results suggested that DNMT1 was the intracellular target of procainamide[1].
Synonyms	Novocainamide, Biocoryl

Chemical Properties

Molecular Weight	235.33
Formula	C₁₃H₂₁N₃O
Cas No.	51-06-9
Smiles	CCN(CC)CCNC(=O)c1ccc(N)cc1

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (191.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2494 mL	21.2468 mL	42.4935 mL	212.4676 mL
5 mM	0.8499 mL	4.2494 mL	8.4987 mL	42.4935 mL
10 mM	0.4249 mL	2.1247 mL	4.2494 mL	21.2468 mL
20 mM	0.2125 mL	1.0623 mL	2.1247 mL	10.6234 mL
50 mM	0.0850 mL	0.4249 mL	0.8499 mL	4.2494 mL
100 mM	0.0425 mL	0.2125 mL	0.4249 mL	2.1247 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc