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Sophocarpine monohydrate

Name: Sophocarpine monohydrate
Brand: TargetMol
SKU: T2746
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2746Cas No. 145572-44-7

Alias Sophocarpine hydrate

Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.

Sophocarpine monohydrate

🥰Excellent

Purity: 99.55%

Catalog No. T2746Alias Sophocarpine hydrateCas No. 145572-44-7

Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.

Pack Size	Price	Availability	Quantity
50 mg	$50	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

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Purity:99.55%

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COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
In vitro	Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. [1] Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. [2] In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM. [3]
In vivo	Administration of 50 mg/kg/d sophocarpine for 5 days from the onset of cachexia does not inhibit the tumor growth but results in attenuation of cachexia symptoms in colon26 adenocarcinoma xenograft BALB/c mice. [1] LD50: Mice 63.94 mg/kg (i.v.) [4]
Synonyms	Sophocarpine hydrate

Chemical Properties

Molecular Weight	246.35
Formula	C₁₅H₂₂N₂O
Cas No.	145572-44-7
Smiles	O.O=C1C=CC[C@@H]2[C@H]3CCCN4CCC[C@@H](CN12)[C@@H]34
Relative Density.	1.19g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (243.56 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0593 mL	20.2963 mL	40.5927 mL	202.9633 mL
5 mM	0.8119 mL	4.0593 mL	8.1185 mL	40.5927 mL
10 mM	0.4059 mL	2.0296 mL	4.0593 mL	20.2963 mL
20 mM	0.2030 mL	1.0148 mL	2.0296 mL	10.1482 mL
50 mM	0.0812 mL	0.4059 mL	0.8119 mL	4.0593 mL
100 mM	0.0406 mL	0.2030 mL	0.4059 mL	2.0296 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc