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α-Lipoic Acid sodium

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Catalog No. T72429Cas No. 2319-84-8
Alias Thioctic acid sodium, DL-α-Lipoic acid sodium, (±)-α-Lipoic acid sodium

α-Lipoic Acid sodium (Thioctic acid sodium) is an antioxidant and essential cofactor for mitochondrial enzyme complexes. It inhibits NF-κB-dependent HIV-1 replication, induces endoplasmic reticulum stress-mediated apoptosis in hepatocellular carcinoma cells, and modulates SREBP-1, FOXO1, and Nrf2 to improve high-fat diet-induced hepatic steatosis.

α-Lipoic Acid sodium
Other Forms of α-Lipoic Acid sodium:

α-Lipoic Acid sodium

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Purity: 99.68%
Catalog No. T72429Alias Thioctic acid sodium, DL-α-Lipoic acid sodium, (±)-α-Lipoic acid sodiumCas No. 2319-84-8
α-Lipoic Acid sodium (Thioctic acid sodium) is an antioxidant and essential cofactor for mitochondrial enzyme complexes. It inhibits NF-κB-dependent HIV-1 replication, induces endoplasmic reticulum stress-mediated apoptosis in hepatocellular carcinoma cells, and modulates SREBP-1, FOXO1, and Nrf2 to improve high-fat diet-induced hepatic steatosis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
100 mg$34-In Stock
500 mg$73-In Stock
1 g$105-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.68%
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Product Introduction

Bioactivity
Description
α-Lipoic Acid sodium (Thioctic acid sodium) is an antioxidant and essential cofactor for mitochondrial enzyme complexes. It inhibits NF-κB-dependent HIV-1 replication, induces endoplasmic reticulum stress-mediated apoptosis in hepatocellular carcinoma cells, and modulates SREBP-1, FOXO1, and Nrf2 to improve high-fat diet-induced hepatic steatosis.
In vitro
α-Lipoic Acid sodium (250, 500, and 1000 μM) significantly increased the NAD⁺/NADH ratio in HepG2 cells; α-Lipoic Acid (50, 125, 250, and 500 μM) enhanced SIRT1 activity in HepG2 cells; α-Lipoic Acid (50, 125, 250, 500, and 100 μM) promoted the phosphorylation levels of AMPK and ACC in HepG2 cells in a dose-dependent manner [1].
In vivo
α-Lipoic Acid sodium (100 mg/kg or 200 mg/kg) significantly reduces visceral fat content in mice on a long-term high-fat diet, while also suppressing appetite and causing a notable decrease in body weight [1].
SynonymsThioctic acid sodium, DL-α-Lipoic acid sodium, (±)-α-Lipoic acid sodium
Chemical Properties
Molecular Weight228.31
FormulaC8H13NaO2S2
Cas No.2319-84-8
SmilesO=C(CCCCC1SSCC1)[O-].[Na+]
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 28 mg/mL (122.64 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM4.3800 mL21.9000 mL43.8001 mL219.0005 mL
5 mM0.8760 mL4.3800 mL8.7600 mL43.8001 mL
10 mM0.4380 mL2.1900 mL4.3800 mL21.9000 mL
20 mM0.2190 mL1.0950 mL2.1900 mL10.9500 mL
50 mM0.0876 mL0.4380 mL0.8760 mL4.3800 mL
100 mM0.0438 mL0.2190 mL0.4380 mL2.1900 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

α-Lipoic Acid sodiumThioctic acid sodium ; (±)-α-Lipoic acid sodium ; DL-α-Lipoic acid sodiumDL-alpha-Lipoic acid sodiumDL-a-Lipoic acid sodiumalpha-Lipoic Acid sodiuma-Lipoic Acid sodium
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