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4,6-O-Ethylidene-α-D-glucose (Synonyms: Ethylidene-glucose)

Name: 4,6-O-Ethylidene-α-D-glucose
Brand: TargetMol
SKU: T72172
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T72172 Copy Product Info

Purity: 99.32%

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4,6-O-Ethylidene-α-D-glucose is a glucose derivative that competitively inhibits the extracellular binding site of glucose transporter 1 (GLUT1), with a Ki of 12 mM for the transport of wild-type 2-deoxy-D-glucose.

4,6-O-Ethylidene-α-D-glucose

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Catalog No. T72172

Synonyms Ethylidene-glucose

Cas No. 13224-99-2

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Pack Size	Price	USA Stock	Global Stock
10 mg	$30	-	In Stock
25 mg	$47	-	In Stock
50 mg	$68	-	In Stock
100 mg	$98	-	In Stock
500 mg	$253	-	In Stock
1 mL x 10 mM (in DMSO)	$39	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.32%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	4,6-O-Ethylidene-α-D-glucose is a glucose derivative that competitively inhibits the extracellular binding site of glucose transporter 1 (GLUT1), with a Ki of 12 mM for the transport of wild-type 2-deoxy-D-glucose.
Targets&IC50	GLUT1:12 mM (Ki)
In vitro	Methods: In vitro inhibition of 4,6-O-ethylidene-α-D-glucose on the transport activity of Plasmodium hexose transporter PfHT1 (wild-type and Gln282-Leu mutant) was determined. Its effects on glucose efflux in human erythrocytes, transmembrane transport mechanism, and related physicochemical properties were also investigated. Results: 1.4,6-O-Ethylidene-α-D-glucose showed extremely low affinity to Plasmodium hexose transporter PfHT1, with Kᵢ > 50 mM. It inhibited wild-type transport with Kᵢ ≈ 12 mM, while the Kᵢ increased to over 120 mM in the Gln282-Leu mutant [1]. 2.4,6-O-Ethylidene-α-D-glucose competitively inhibited glucose efflux, but its entry into human erythrocytes was not affected by glucose in the medium. It did not enhance the potentiating effect of medium glucose on FDNB inhibition; instead, it exerted a slight protective effect. 3.4,6-O-Ethylidene-α-D-glucose entered human erythrocytes via simple diffusion, supported by similar penetration rates in guinea pig erythrocytes, induction of osmotic hemolysis in isotonic solutions independent of Cu²⁺, and a high ether/water partition coefficient [3].
Synonyms	Ethylidene-glucose

Chemical Properties

Molecular Weight	206.19
Formula	C₈H₁₄O₆
Cas No.	13224-99-2
Smiles	O[C@H]1[C@]2([C@](O[C@H](O)[C@@H]1O)(COC(C)O2)[H])[H]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (387.99 mM), Sonication is recommended.

H2O: 100 mg/mL (484.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	4.8499 mL	24.2495 mL	48.4990 mL	242.4948 mL
5 mM	0.9700 mL	4.8499 mL	9.6998 mL	48.4990 mL
10 mM	0.4850 mL	2.4249 mL	4.8499 mL	24.2495 mL
20 mM	0.2425 mL	1.2125 mL	2.4249 mL	12.1247 mL
50 mM	0.0970 mL	0.4850 mL	0.9700 mL	4.8499 mL
100 mM	0.0485 mL	0.2425 mL	0.4850 mL	2.4249 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc