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N-trans-Feruloyltyramine

Name: N-trans-Feruloyltyramine
Brand: TargetMol
SKU: T3S0645
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3S0645Cas No. 66648-43-9

Alias N-Feruloyltyramine, Moupinamide

1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-selectin expression on platelets, is a platelet aggregation inhibitor. 4. NTF inhibits melanogenesis in a dose-dependent manner, NTF induces downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells.

N-trans-Feruloyltyramine

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Purity: 99.67%

Catalog No. T3S0645Alias N-Feruloyltyramine, MoupinamideCas No. 66648-43-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	In Stock	In Stock
5 mg	$178	In Stock	In Stock
10 mg	$297	In Stock	In Stock
25 mg	$516	In Stock	In Stock
50 mg	$736	In Stock	In Stock
100 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$123	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.67%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

N-trans-Feruloyltyramine AI Summary

N-trans-Feruloyltyramine exhibits a wide range of biological activities, including inhibitory, cytotoxic, antimicrobial, anti-inflammatory, antioxidant, hepatoprotective, and antiproliferative effects. It demonstrates significant inhibitory activity against tyrosinase (49.0% at 100 μM), alpha-glucosidase (IC50 = 10620.0 nM), and Saccharomyces cerevisiae alpha-glucosidase (IC50 = 24700.0 nM). It also shows cytotoxic effects against various cell lines such as HepG2, A549, MCF7, HT-29, LNCAP, MDA-MB-435, KB, and Vero cells, with IC50 values ranging from 1.9 μg/mL to greater than 20,000.0 nM. Additionally, N-trans-Feruloyltyramine possesses antibacterial activity with MIC values of 62.5 μg/mL to greater than 700.0 μg/mL against several bacterial strains, including Staphylococcus aureus, Micrococcus luteus, and others. It exhibits antimyocobacterial activity against Mycobacterium tuberculosis H37Rv (MIC = 60.0 μg/mL), and antiproliferative activity against a multitude of human cell lines, such as MGC-803, HGC-27, and GES1, with IC50 values up to 150,000.0 nM. The compound is also noted for its anti-inflammatory properties, inhibiting NO production in mouse BV2 cells (IC50 = 18000.0 nM) and PGE2 production in RAW264.7 cells (IC50 = 6330.0 nM). It demonstrates antioxidant activity (IC50 = 41200.0 nM in DPPH assays) and a weak inhibition of mushroom tyrosinase (IC50 > 5000000.0 nM). The compound showcases a moderate to low cytotoxic effect against human HepG2 cells, HepG2(2.2.15) cells, and other cell lines at varying concentrations. Moreover, N-trans-Feruloyltyramine has exhibited permeability through the blood-brain barrier as indicated by its PAMPA-BBB retention time of 28.42 minutes and shows hepatoprotective activity by inhibiting APAP-induced cell damage in human HepG2 cells (3.5% inhibition at 10 μM). It also demonstrates brine shrimp larvae toxicity with an LC50 of 6.7 μg/mL and antiplasmodial activity against Plasmodium falciparum TM4 and K1 strains with IC50 values greater than 47800.0 nM and 54900.0 nM, respectively. Lastly, N-trans-Feruloyltyramine shows anticomplement activity, with IC50 values for hemolytic inhibition through classic and alternative pathways being 880000.0 nM and 1330000.0 nM, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

N-Feruloyltyramine, Moupinamide

Chemical Properties

Molecular Weight	313.35
Formula	C₁₈H₁₉NO₄
Cas No.	66648-43-9
Smiles	COc1cc(\C=C\C(=O)NCCc2ccc(O)cc2)ccc1O
Relative Density.	1.248g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 12 mg/mL (38.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.38 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1913 mL	15.9566 mL	31.9132 mL	159.5660 mL
5 mM	0.6383 mL	3.1913 mL	6.3826 mL	31.9132 mL
10 mM	0.3191 mL	1.5957 mL	3.1913 mL	15.9566 mL
20 mM	0.1596 mL	0.7978 mL	1.5957 mL	7.9783 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc