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Dihydrocaffeic acid

Name: Dihydrocaffeic acid
Brand: TargetMol
SKU: T0539
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0539Cas No. 1078-61-1

Dihydrocaffeic acid is a metabolite of chlorogenic acid, a well-known antioxidant component with antioxidant, anti-Alzheimer's disease, neuroprotective, arousal and lipid-lowering effects.

Dihydrocaffeic acid

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Purity: 98.63%

Catalog No. T0539Cas No. 1078-61-1

Dihydrocaffeic acid is a metabolite of chlorogenic acid, a well-known antioxidant component with antioxidant, anti-Alzheimer's disease, neuroprotective, arousal and lipid-lowering effects.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$35	In Stock	In Stock
100 mg	$54	In Stock	In Stock
500 mg	$128	In Stock	In Stock
1 g	$189	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$31	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.63%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Dihydrocaffeic acid AI Summary

Dihydrocaffeic acid exhibits diverse bioactivities across multiple domains including taste perception, cytotoxicity, enzyme inhibition, antioxidant properties, antihypertensive effects, and antiviral activities. At a concentration of 250 ppm, it has a perceived taste intensity of 0.73, characterized by sour (76.0%), bitter (15.0%), and other taste (9.0%) profiles, and an aftertaste reported by 50% of judgments. It shows significant cytotoxic activity against HeLa cells, reducing cell density from 5 million to 500,000 cells per mL after 72 hours. Additionally, it inhibits Escherichia coli M15 DXR by 26.2% at 100 µM and demonstrates an 86.0% inhibition of HDAC activity at 500 µM in HeLa cells. In Wistar rats, Dihydrocaffeic acid shows antihypertensive activity at 10 mg/kg/day by reducing various blood markers over 8 weeks and exhibits potential synergistic effects with losartan. The compound also has antioxidant properties, evidenced by inhibition of AAPH-induced lipid peroxidation, and ABTS and DPPH radical scavenging activities, with specific IC50 values for DPPH and ABTS radicals being 24800.0 nM and 24000.0 nM, respectively. It demonstrates a weak inhibitory effect on SMAD transcription factor with an IC50 value greater than 50,000.0 nM and shows moderate inhibition of HDAC activity in human cells. The compound also performs as an antagonist for the Gloeobacter violaceus ligand-gated ion channel with a 90.5% inhibition rate at pH 5.5 and an IC50 value of 86800.0 nM. Dihydrocaffeic acid is a potent antiviral agent against various viruses like Poliovirus and Herpes simplex virus, with an ID50 greater than 200.0 µg/ml, and exhibits no significant cytotoxicity to various cultured human and monkey cells at the tested concentrations. It inhibits enzymatic activities like Pseudomonas aeruginosa PqsD (IC50 = 27000.0 nM) and the interaction between CMG2 and PA expressed in Escherichia coli with an IC50 greater than 300,000.0 nM. Additionally, it inhibits the human TAS2R39 receptor in HEK293 cells with a 30.0% reduction in calcium release at 10 mM. Overall, Dihydrocaffeic acid is a multi-faceted bioactive compound with significant implications in biomedicine and pharmacology, especially notable for its cytotoxic, antihypertensive, antioxidant, and antiviral activities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Dihydrocaffeic acid is a metabolite of chlorogenic acid, a well-known antioxidant component with antioxidant, anti-Alzheimer's disease, neuroprotective, arousal and lipid-lowering effects.

Chemical Properties

Molecular Weight	182.17
Formula	C₉H₁₀O₄
Cas No.	1078-61-1
Smiles	OC(=O)CCc1ccc(O)c(O)c1
Relative Density.	1.398 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1372.34 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4894 mL	27.4469 mL	54.8938 mL	274.4689 mL
5 mM	1.0979 mL	5.4894 mL	10.9788 mL	54.8938 mL
10 mM	0.5489 mL	2.7447 mL	5.4894 mL	27.4469 mL
20 mM	0.2745 mL	1.3723 mL	2.7447 mL	13.7234 mL
50 mM	0.1098 mL	0.5489 mL	1.0979 mL	5.4894 mL
100 mM	0.0549 mL	0.2745 mL	0.5489 mL	2.7447 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc