Guanethidine

Name: Guanethidine
Brand: TargetMol
SKU: T50109
Rating: 4.5 (1 reviews)

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Catalog No. T50109Cas No. 55-65-2

Guanethidine sulphate, synthesized in 1959, is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.

Guanethidine

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Catalog No. T50109Cas No. 55-65-2

Guanethidine sulphate, synthesized in 1959, is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	Inquiry	6-8 weeks	6-8 weeks
500 mg	Inquiry	6-8 weeks	6-8 weeks

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Product Introduction

Bioactivity

Description	Guanethidine sulphate, synthesized in 1959, is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.
In vitro	Sympathetic fibers ablation is associated with a loss of rat endothelial cell marker (RECA), but no significant effect of guanethidine was found on the survival of endothelial cells and mesenchymal stem cells in vitro [1].
In vivo	Guanethidine (30 mg/kg, s.c., 1 h) administration does not alter IL-18 induced hypernociception in TNFR1 (-/-) mice, indicating that this sympathetic blocker is ineffective in this context [2]. This outcome was observed in a study involving WT Balb/c, TNFR1 (-/-), and IFN-γ (-/-) mice, with guanethidine diluted in saline.

Chemical Properties

Molecular Weight	198.31
Formula	C₁₀H₂₂N₄
Cas No.	55-65-2
Relative Density.	1.13g/cm3

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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