Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PAA4, a methide carbon-centered polynuclear Au(I) cluster, exhibits antiproliferative activity and induces pH2AX expression in a time-dependent manner. It also demonstrates an anti-tumor effect in an orthotopic bladder cancer mouse model [1].
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Description | PAA4, a methide carbon-centered polynuclear Au(I) cluster, exhibits antiproliferative activity and induces pH2AX expression in a time-dependent manner. It also demonstrates an anti-tumor effect in an orthotopic bladder cancer mouse model [1]. |
In vitro | PAA4, at concentrations ranging from 0 to 4 µM over a 24-hour period, does not exhibit notable cytotoxic effects on EJ, HUVEC, and SV-HUC-1 cell lines, with IC50 values recorded at 2. |
In vivo | PAA4, administered intravesically at a concentration of 1.5 µM in a volume of 100 µL, exhibited anti-tumor effects in a murine model. The compound was delivered five times on alternating days over a span of eight days [1]. |
Molecular Weight | N/A |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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