Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AChE/Aβ-IN-2 (compound 33) is a powerful, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 135 nM. It also functions as an NMDA receptor antagonist (GluN1-1b/GluN2B subunit combination) with an IC50 of 5.054 μM, inhibits Aβ aggregation, and exhibits favorable blood-brain barrier permeability. Additionally, it enhances cognitive and spatial memory in a rat model [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | AChE/Aβ-IN-2 (compound 33) is a powerful, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 135 nM. It also functions as an NMDA receptor antagonist (GluN1-1b/GluN2B subunit combination) with an IC50 of 5.054 μM, inhibits Aβ aggregation, and exhibits favorable blood-brain barrier permeability. Additionally, it enhances cognitive and spatial memory in a rat model [1]. |
In vitro | Compound 33 (AChE/Aβ-IN-2) at a concentration range of 5-20 μM over 48 hours inhibits the aggregation of Aβ1-42 at 10 μM [1]. |
In vivo | Compound 33 (AChE/Aβ-IN-2), administered orally at a dosage of 10 mg/kg/day for 7 days, attenuated memory deficits in rats induced by Aβ1-42 and reduced the time spent in the target quadrant of the Morris water maze [1]. |
Molecular Weight | 356.89 |
Formula | C20H25ClN4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AChE/Aβ-IN-2 inhibitor inhibit