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human GIP(3-30), amide

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Catalog No. TP2586Cas No. 1884226-05-4

human GIP(3-30), amide is a high-affinity human GIP receptor antagonist and a natural metabolite of DPP-4 cleavage of GIP(1-30)NH₂. Human GIP(3-30), amide inhibits insulin secretion in vitro and suppresses cAMP and β-arrestin 1/2 recruitment induced by GIP(1-42).

human GIP(3-30), amide

human GIP(3-30), amide

😃Good
Purity: 99.19%
Catalog No. TP2586Cas No. 1884226-05-4
human GIP(3-30), amide is a high-affinity human GIP receptor antagonist and a natural metabolite of DPP-4 cleavage of GIP(1-30)NH₂. Human GIP(3-30), amide inhibits insulin secretion in vitro and suppresses cAMP and β-arrestin 1/2 recruitment induced by GIP(1-42).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$74-In Stock
5 mg$179-In Stock
10 mg$297-In Stock
25 mg$492-In Stock
50 mg$717-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.19%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
human GIP(3-30), amide is a high-affinity human GIP receptor antagonist and a natural metabolite of DPP-4 cleavage of GIP(1-30)NH₂. Human GIP(3-30), amide inhibits insulin secretion in vitro and suppresses cAMP and β-arrestin 1/2 recruitment induced by GIP(1-42).
In vitro
human GIP(3-30), amide at concentrations of 0.01-10 µM for 20 minutes competitively binds to GIPR, blocking GIP-mediated cAMP accumulation (Ki=16.8 nM), β-arrestin-1/2 recruitment (Ki = 10.6 nM/10.2 nM), and receptor internalization [2].
Human GIP(3-30), amide at concentrations of 0.01-10 µM for 30 minutes, inhibits GIP-mediated insulin secretion and signal transduction in adipocytes [2].
Chemical Properties
Molecular Weight3297.69
FormulaC150H226N38O44S
Cas No.1884226-05-4
SmilesC([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N)=O)=O)CCC(N)=O)=O)C)=O)CC(C)C)=O)CC(C)C)=O)NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=C(O)C=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CC=CC=C4)NC([C@@H](NC(CNC([C@H](CCC(O)=O)N)=O)=O)[C@@H](C)O)=O)=O)[C@H](CC)C)=O)CO)=O)CC(O)=O)=O)=O)CO)=O)[C@H](CC)C)=O)C)=O)CCSC)=O)CC(O)=O)=O)CCCCN)=O)[C@H](CC)C)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CC(O)=O)=O)=O)[C@@H](C)C)=O)CC(N)=O)=O)C=5C=6C(NC5)=CC=CC6
SequenceGlu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-NH2
Sequence ShortEGTFISDYSIAMDKIHQQDFVNWLLAQK
Storage & Solubility Information
Storagekeep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: ≥ 80 mg/mL, Sonication is recommended.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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