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IP2

Catalog No. T82056

IP2, an immunomodulatory agent, enhances PTP (Pioneer Translation Product)-derived antigen presentation in cancer cells without exhibiting cytotoxicity. Additionally, IP2 has been shown to induce tumor growth defects in mouse models [1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

IP2, CAS N/A

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	IP2, an immunomodulatory agent, enhances PTP (Pioneer Translation Product)-derived antigen presentation in cancer cells without exhibiting cytotoxicity. Additionally, IP2 has been shown to induce tumor growth defects in mouse models [1].
In vitro	IP2 (35 µM) exhibits immunomodulatory activity in murine MCA205 fibrosarcoma cells [1].
In vivo	IP2 demonstrates high bioavailability in mice at dosage levels of 0.711 mg/kg intraperitoneally (i.p.) and 9.103 mg/kg intravenously (i.v.), and in dogs at 26.76 mg/kg i.v. [1]. When administered i.p. to C57BL/6 mice at a range of 50 to 500 mg/kg, IP2 is well-tolerated [1]. Furthermore, at 2.5 mg/kg i.v. and 5 mg/kg via direct intratumoral injection thrice weekly for two weeks, IP2 significantly inhibits tumor growth in C57BL/6 mice [1]. Pharmacokinetic parameters for IP2 in male C57BL/6J mice and male beagle dogs reveal the following: intraperitoneally administered to mice, IP2 has a maximal concentration (C max) of 2078 ng/mL, time to reach maximum concentration (T max) of 0.0833 hours, half-life (T 1/2) of 0.8 hours, clearance (CL) of 154 mL/min/kg, bioavailability (F) of 86%, mean residence time from 0 to time t (MRT 0-t) of 0.7 hours, and area under the curve (AUC) tot of 982.3 ng/mL·h with extraparent percent (AUC extra) of 1.3%. When administered intravenously to mice, the corresponding values are a C max of 322.7 ng/mL, T max of 0.0833 hours, T 1/2 of 1.1 hours, CL of 133 mL/min/kg, F of 0.9%, MRT 0-t of 88.8 hours, AUC tot of 15.2 ng/mL·h. In dogs, the compound shows a C max of 272 µg/mL, T max of 0.0833 hours, T 1/2 of 3.8 hours, CL of 0.69 mL/min/kg, F of 3.8%, MRT 0-t of 654.7 µg/mL·h, and AUC extra of 0.9% [1].

Molecular Weight

N/A

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Dose Conversion

You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

IP2 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.