17R(18S)-EpETE

Name: 17R(18S)-EpETE
Brand: TargetMol
SKU: T36215
Rating: 4.5 (1 reviews)

(Synonyms: 17(R),18(S)-EETeTr, (17R,18S)-Epoxyeicosatetraenoic acid) Copy Product Info

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Synonyms: 17(R),18(S)-EETeTr, (17R,18S)-Epoxyeicosatetraenoic acid

Catalog No. T36215 Copy Product Info

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17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid. 17R(18S)-EpETE activates large-conductance calcium-activated potassium (BKCa) channels, increasing potassium current amplitude by 15-fold in isolated rat cerebral artery vascular smooth muscle cells at +60 mV at 50 nM. 17R(18S)-EpETE also exerts negative chronotropic effects in neonatal rat cardiomyocytes with an EC50 of ~1–2 nM and prevents calcium-induced increases in spontaneous beating. 17R(18S)-EpETE is therefore used in cardiovascular electrophysiology research systems to investigate ion channel modulation, lipid mediator signaling, and cardiac excitability regulation in cellular models.

Cas No. 725246-18-4

Pack Size	Price	USA Stock	Global Stock	Quantity
50 µg	$323	35 days	35 days
100 µg	$596	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description

Synonyms

17(R),18(S)-EETeTr, (17R,18S)-Epoxyeicosatetraenoic acid

Chemical Properties

Molecular Weight	318.45
Formula	C₂₀H₃₀O₃
Cas No.	725246-18-4
Smiles	C(/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O)[C@@H]1[C@H](CC)O1

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	Ethanol: Soluble

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc