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BCMA/TNFRSF17 Protein, Human, Recombinant (His & Flag)
(Synonyms: Tumor necrosis factor receptor superfamily member 17, Tnfrsf17, CD269, Bcma, Bcm, B-cell maturation protein) Copy Product InfoSynonyms: Tumor necrosis factor receptor superfamily member 17, Tnfrsf17, CD269, Bcma, Bcm, B-cell maturation protein
Catalog No. TMPJ-00066 Copy Product Info
B cell maturation antigen (BCMA) is a member of the TNF receptor superfamily. It has been designated TNFRSF17. Mouse BCMA is a 185 amino acid (aa) protein consisting of a 49 aa extracellular domain, a 23 aa transmembrane domain, and a 113 aa intracellular domain. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development,function and regulation.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $55 | 7-10 days | 7-10 days | |
| 10 μg | $86 | 7-10 days | 7-10 days | |
| 20 μg | $137 | 7-10 days | 7-10 days | |
| 50 μg | $262 | 7-10 days | 7-10 days | |
| 100 μg | $482 | 7-10 days | 7-10 days | |
| 200 μg | $892 | 7-10 days | 7-10 days | |
| 500 μg | $2,030 | 7-10 days | 7-10 days | |
| 1 mg | $3,030 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:Greater than 95% as determined by reducing SDS-PAGE.
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Human BCMA-His-Flag at 1μg/ml (100 μl/well)can bind Human BAFF-Fc. The ED50 of Human BAFF-Fc is 13.62 ng/ml. (Regularly tested) |
| Description | B cell maturation antigen (BCMA) is a member of the TNF receptor superfamily. It has been designated TNFRSF17. Mouse BCMA is a 185 amino acid (aa) protein consisting of a 49 aa extracellular domain, a 23 aa transmembrane domain, and a 113 aa intracellular domain. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development,function and regulation. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | N-6xHis-Flag |
| Accession Number | Q02223 |
| Amino Acid | Met1-Ala54 |
| Construction | Met1-Ala54 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC. |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | Tumor necrosis factor receptor superfamily member 17, Tnfrsf17, CD269, Bcma, Bcm, B-cell maturation protein |
| Research Background |
| Molecular Weight | (11-14)&(16-26) KDa (reducing condition) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: BCMA/TNFRSF17 Protein, Human, Recombinant (His & Flag) chemical structure | BCMA/TNFRSF17 Protein, Human, Recombinant (His & Flag) molecular weight
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